Rational and semirational protein design

Research output: Chapter in Book/Entry/PoemChapter

63 Scopus citations


This mini review gives an overview over different design approaches and methodologies applied in rational and semirational enzyme engineering. The underlying principles for engineering novel activities, enantioselectivity, substrate specificity, stability, and pH optimum are summarized.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages9
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Computational enzyme design
  • De novo enzyme design
  • Enantioselectivity
  • Molecular docking
  • Molecular dynamics
  • Rational protein design
  • Substrate specificity
  • Thermostability
  • pH optimum

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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