Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical projection stereolithography

A. Ping Zhang, Xin Qu, Pranav Soman, Kolin C. Hribar, Jin W. Lee, Shaochen Chen, Sailing He

Research output: Contribution to journalArticlepeer-review

215 Scopus citations

Abstract

The topographic features of the extracelluar matrix (ECM) lay the foundation for cellular behavior. A novel biofabrication method using a digital-mirror device (DMD), called dynamic optical projection stereolithography (DOPsL) is demonstrated. This robust and versatile platform can generate complex biomimetic scaffolds within seconds. Such 3D scaffolds have promising potentials for studying cell interactions with microenvironments in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)4266-4270
Number of pages5
JournalAdvanced Materials
Volume24
Issue number31
DOIs
StatePublished - Aug 16 2012
Externally publishedYes

Keywords

  • cell culture
  • extracelluar microenviroment
  • maskless lithography
  • optical projection stereolithography
  • soft material

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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