Racial Differences in Aortic Stiffness in Children

Wesley K. Lefferts, Jacqueline A. Augustine, Nicole L. Spartano, Nader H. Atallah-Yunes, Kevin S Heffernan, Brooks B Gump

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To investigate racial differences in central blood pressure and vascular structure/function as subclinical markers of atherosclerotic cardiovascular disease in children. Study design This cross-sectional study recruited 54 African American children (18 female, 36 male; age 10.5 ± 0.9 years) and 54 white children (27 female, 26 male; age 10.8 ± 0.9 years) from the Syracuse City community as part of the Environmental Exposures and Child Health Outcomes study. Participants underwent blood lipid and vascular testing on 2 separate days. Carotid artery intima-media thickness and aortic stiffness were measured by ultrasonography and carotid-femoral pulse wave velocity, respectively. Blood pressure was assessed at the brachial artery and estimated in the carotid artery using applanation tonometry. Results African American children had significantly higher pulse wave velocity (4.8 ± 0.8 m/s) compared with white children (4.2 ± 0.7 m/s; P < .05), which remained significant after adjustment for confounding variables including socioeconomic status. African American children had significantly higher intima-media thickness (African American 0.41 ± 0.06, white 0.39 ± 0.05 mm), and carotid systolic blood pressure (African American 106 ± 11, white 102 ± 8 mm Hg; P < .05) compared with white children, although these racial differences were no longer present after covariate adjustments for height. Conclusions Racial differences in aortic stiffness are present in childhood. Our findings suggest that racial differences in subclinical cardiovascular disease occur earlier than previously recognized.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalJournal of Pediatrics
Volume180
DOIs
StatePublished - Jan 1 2017

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Vascular Stiffness
African Americans
Blood Pressure
Pulse Wave Analysis
Carotid Arteries
Blood Vessels
Cardiovascular Diseases
Carotid Intima-Media Thickness
Confounding Factors (Epidemiology)
Brachial Artery
Environmental Health
Environmental Exposure
Manometry
Thigh
Social Class
Ultrasonography
Cross-Sectional Studies
Outcome Assessment (Health Care)
Lipids

Keywords

  • arterial stiffness
  • central blood pressure
  • pediatrics
  • race

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Racial Differences in Aortic Stiffness in Children. / Lefferts, Wesley K.; Augustine, Jacqueline A.; Spartano, Nicole L.; Atallah-Yunes, Nader H.; Heffernan, Kevin S; Gump, Brooks B.

In: Journal of Pediatrics, Vol. 180, 01.01.2017, p. 62-67.

Research output: Contribution to journalArticle

Lefferts, WK, Augustine, JA, Spartano, NL, Atallah-Yunes, NH, Heffernan, KS & Gump, BB 2017, 'Racial Differences in Aortic Stiffness in Children', Journal of Pediatrics, vol. 180, pp. 62-67. https://doi.org/10.1016/j.jpeds.2016.09.071
Lefferts, Wesley K. ; Augustine, Jacqueline A. ; Spartano, Nicole L. ; Atallah-Yunes, Nader H. ; Heffernan, Kevin S ; Gump, Brooks B. / Racial Differences in Aortic Stiffness in Children. In: Journal of Pediatrics. 2017 ; Vol. 180. pp. 62-67.
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