Quiet breathing in hindlimb casted mice

Candace N. Receno, Katelynn E. Roffo, Marisa C. Mickey, Keith C Deruisseau, Lara R. DeRuisseau

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The hindlimb casting model was developed to study skeletal muscle reloading following a period of unloading. It is unknown if ventilation parameters of mice are affected by the casting model. We tested the hypothesis that hindlimb casted mice have similar ventilatory patterns compared to mice with the casts removed. Male CD-1 mice underwent 14 days of hindlimb immobilization via plaster casting. Breathing parameters were obtained utilizing unrestrained barometric plethysmography (UBP). Breathing traces were analyzed with Ponemah software for breathing frequency, tidal volume (TV), and minute ventilation (MV). Frequency, TV and MV did not show any differences in quiet breathing patterns during or post-casting in mice. Thus, the hindlimb casting model does not complicate breathing during and after casting and should not interfere with the unloading and reloading of skeletal muscle.

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalRespiratory Physiology and Neurobiology
StatePublished - Dec 2018


  • Breathing
  • Immobilization
  • Plaster casting
  • Unrestrained barometric plethysmography
  • Ventilation

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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