TY - GEN
T1 - Quantification of the kinetics and thermodynamics of protein adsorption using atomic force microscopy
AU - Gettens, R.
AU - Gilbert, J. L.
AU - Bai, Z.
PY - 2004
Y1 - 2004
N2 - A set of rules on specific material properties that effect protein adsorption and conformation to device surfaces was developed. The protein used was bovine plasma fibrinogen in a pH 7.4 phosphate buffered saline solute and the substrate used was Grade IV muscovite mica. It was observed that the bolus method, one of the methods used in the study, gave superior imaging resolution while the sample was in-situ. It was suggested that by using the fluid flow method, it was possible to obtain real time kinetic data while being able to introduce the shear effects that would be present in blood contacting devices in the circulatory system.
AB - A set of rules on specific material properties that effect protein adsorption and conformation to device surfaces was developed. The protein used was bovine plasma fibrinogen in a pH 7.4 phosphate buffered saline solute and the substrate used was Grade IV muscovite mica. It was observed that the bolus method, one of the methods used in the study, gave superior imaging resolution while the sample was in-situ. It was suggested that by using the fluid flow method, it was possible to obtain real time kinetic data while being able to introduce the shear effects that would be present in blood contacting devices in the circulatory system.
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M3 - Conference contribution
AN - SCOPUS:13844276269
SN - 1877040193
SN - 9781877040191
T3 - Transactions - 7th World Biomaterials Congress
SP - 1739
BT - Transactions - 7th World Biomaterials Congress
T2 - Transactions - 7th World Biomaterials Congress
Y2 - 17 May 2004 through 21 May 2004
ER -