Protein Synthesis and Memory

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The need for training-initiated protein synthesis for memory formation is the prevalent view for mechanisms of memory consolidation. This theory states that memory passes through at least two phases after an experience: a protein synthesis-independent phase that lasts for a few hours after training and a protein synthesis-dependent phase in which new proteins are produced after training are responsible for the ultimate neuronal changes that store and then maintain memory for that learned event. However, this purported fundamental property of memory formation is not fully supported by many findings and is actually contradicted by some of those findings. This chapter reviews many of these discrepancies, some based on recent results confirming findings obtained decades ago and some based on novel findings. Topics include the following: (1) studies of the time-limited phases of memory formation based on protein synthesis inhibitors that reveal a very wide range of times, from seconds to weeks, for memory formation; (2) there are many examples showing that training and synaptic plasticity are not always impaired by protein synthesis inhibitors; (3) many treatments rescue memory impaired by protein synthesis inhibitors while not interfering with the ability of these inhibitors to block protein synthesis; and (4) Specific neurobiological consequences of protein synthesis inhibition, in addition to more specific side effects of various protein synthesis inhibitors, appear to mediate the effects of the inhibitors on memory. Taken together the evidence points to a weak foundation for a theory of memory formation based on an early protein synthesis-independent phase of memory followed by a protein synthesis-dependent phase of memory. Instead, these experiments provide information about mechanisms mediating amnesia, which need not be the inverse of the mechanisms underlying memory.

Original languageEnglish (US)
Title of host publicationLearning and Memory
Subtitle of host publicationA Comprehensive Reference
PublisherElsevier
Pages293-310
Number of pages18
ISBN (Print)9780128052914
DOIs
StatePublished - Jan 1 2017

Fingerprint

Proteins
Protein Synthesis Inhibitors
Neuronal Plasticity
Aptitude
Amnesia

Keywords

  • Amnesia
  • Anisomycin
  • Cycloheximide
  • Long-term memory
  • Memory consolidation
  • Memory modulation
  • Protein synthesis inhibition
  • Protein synthesis-dependent memory
  • Protein synthesis-independent memory
  • Puromycin
  • Short-term memory

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Gold, P. E. (2017). Protein Synthesis and Memory. In Learning and Memory: A Comprehensive Reference (pp. 293-310). Elsevier. https://doi.org/10.1016/B978-0-12-809324-5.21119-X

Protein Synthesis and Memory. / Gold, Paul Ernest.

Learning and Memory: A Comprehensive Reference. Elsevier, 2017. p. 293-310.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gold, PE 2017, Protein Synthesis and Memory. in Learning and Memory: A Comprehensive Reference. Elsevier, pp. 293-310. https://doi.org/10.1016/B978-0-12-809324-5.21119-X
Gold PE. Protein Synthesis and Memory. In Learning and Memory: A Comprehensive Reference. Elsevier. 2017. p. 293-310 https://doi.org/10.1016/B978-0-12-809324-5.21119-X
Gold, Paul Ernest. / Protein Synthesis and Memory. Learning and Memory: A Comprehensive Reference. Elsevier, 2017. pp. 293-310
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