Propagating Stress Waves during Epithelial Expansion

Shiladitya Banerjee, Kazage J.C. Utuje, M. Cristina Marchetti

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Coordinated motion of cell monolayers during epithelial wound healing and tissue morphogenesis involves mechanical stress generation. Here we propose a model for the dynamics of epithelial expansion that couples mechanical deformations in the tissue to contractile activity and polarization in the cells. A new ingredient of our model is a feedback between local strain, polarization, and contractility that naturally yields a mechanism for viscoelasticity and effective inertia in the cell monolayer. Using a combination of analytical and numerical techniques, we demonstrate that our model quantitatively reproduces many experimental findings [Nat. Phys. 8, 628 (2012)], including the buildup of intercellular stresses, and the existence of traveling mechanical waves guiding the oscillatory monolayer expansion.

Original languageEnglish (US)
Article number228101
JournalPhysical Review Letters
Volume114
Issue number22
DOIs
StatePublished - Jun 2 2015

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Banerjee, S., Utuje, K. J. C., & Marchetti, M. C. (2015). Propagating Stress Waves during Epithelial Expansion. Physical Review Letters, 114(22), [228101]. https://doi.org/10.1103/PhysRevLett.114.228101