Promises, challenges and future directions of μCCAs

Mandy B. Esch, Jong H. Sung, Michael L. Shuler

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Micro-cell culture analogs (μCCAs) are a class of in vitro tissue analogs that combine multiple organ analogs on one microfluidic platform in physiologically correct volume ratios. The microfluidic platform also provides fluid flow rates and substance residence times close to those present in the human body. Several advantages arise from the microfluidic format that can be exploited for realistic simulations of drug absorption, metabolism and action. We envision that, together with theoretical modeling, μCCAs may produce reliable predictions of the efficacy of newly developed drugs. Advantages, challenges, and future directions of μCCAs are discussed and examples of systems are provided.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalJournal of Biotechnology
Volume148
Issue number1
DOIs
StatePublished - Jul 1 2010

Keywords

  • Body on a chip
  • In vitro tissue
  • Micro-cell culture analog
  • Microfluidics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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