Progress in the noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood

J. Chaiken, W. F. Finney, X. Yang, P. E. Knudson, K. P. Peterson, C. M. Peterson, R. S. Weinstock, D. Hagrman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.

Original languageEnglish (US)
Pages (from-to)216-227
Number of pages12
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001


  • Blood analysis
  • In vivo Raman spectroscopy
  • Microcirculation
  • Noninvasive

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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