Progress in the noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood

J. Chaiken; W. F. Finney; X. Yang; P. E. Knudson; K. P. Peterson; C. M. Peterson; R. S. Weinstock; D. Hagrman

doi:10.1117/12.427936

Progress in the noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood

J. Chaiken, W. F. Finney, X. Yang, P. E. Knudson, K. P. Peterson, C. M. Peterson, R. S. Weinstock, D. Hagrman

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.

Original language	English (US)
Pages (from-to)	216-227
Number of pages	12
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4254
DOIs	https://doi.org/10.1117/12.427936
State	Published - 2001

Keywords

Blood analysis
In vivo Raman spectroscopy
Microcirculation
Noninvasive

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.427936

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abstract = "We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.",

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AU - Chaiken, J.

AU - Finney, W. F.

AU - Yang, X.

AU - Knudson, P. E.

AU - Peterson, K. P.

AU - Peterson, C. M.

AU - Weinstock, R. S.

AU - Hagrman, D.

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AB - We have recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. New clinical data from individuals and groups completely reproduce and extend all the earlier results. These new data reveal how certain small differences between individuals result in some variability in their noninvasive quantitation. We show the origin of this variability and how to obtain quantitative corrections based entirely on the individual measurement and tabulated data.

KW - Blood analysis

KW - In vivo Raman spectroscopy

KW - Microcirculation

KW - Noninvasive

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Progress in the noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood

Abstract

Keywords

ASJC Scopus subject areas

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