Probing mechanisms of bacterial infection through molecular dynamics simulations

S. C. Desalvo, Y. Liu, Shikha Nangia, Radhakrishna Sureshkumar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biofilms are colonies of bacteria that thrive and proliferate in the living host causing infection. Inside the living tissue, the bacterial biofilms interact with the host cells through chemicals known as signaling factors. The signaling factors are relatively small polypeptides that have profound effects on the cellular activities of the host. The less understood, complex signaling process determines the survival of either the biofilm or the host cells. This proceeding details the process and preliminary results of the computational study of the translocation of tumor necrosis factor-alpha and granulocyte macrophage colony stimulating factor signaling factors across a model cell membrane.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Pages41-42
Number of pages2
DOIs
StatePublished - 2013
Event39th Annual Northeast Bioengineering Conference, NEBEC 2013 - Syracuse, NY, United States
Duration: Apr 5 2013Apr 7 2013

Other

Other39th Annual Northeast Bioengineering Conference, NEBEC 2013
CountryUnited States
CitySyracuse, NY
Period4/5/134/7/13

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Keywords

  • Biofilm
  • Coarse-Graining
  • granulocyte macrophage colony stimulating factor
  • Lipid Bilayer
  • Molecular Dynamics
  • Potential of Mean Force
  • Signaling Factor
  • Tumor Necrosis Factor - Alpha

ASJC Scopus subject areas

  • Bioengineering

Cite this

Desalvo, S. C., Liu, Y., Nangia, S., & Sureshkumar, R. (2013). Probing mechanisms of bacterial infection through molecular dynamics simulations. In Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC (pp. 41-42). [6574347] https://doi.org/10.1109/NEBEC.2013.129