Preservation of osteogenic capacity following shape memory triggering of foam and e-spun scaffolds

J. Wang; L. F. Tseng; R. M. Baker; James H Henderson

doi:10.1109/NEBEC.2015.7117135

Preservation of osteogenic capacity following shape memory triggering of foam and e-spun scaffolds

J. Wang, L. F. Tseng, R. M. Baker, James H Henderson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Shape memory polymers (SMPs) have received significant attention for their potential to be applied in the development of dynamic, functional scaffolds for tissue engineering and regenerative medicine. Recent work has employed shape memory polymers in the development of topography-changing substrates, and these studies have shown that changes in topography can direct cell alignment, cell migration, and stem cell lineage commitment. Additional efforts have focused on expanding these strategies to 3D scaffolds that are capable of undergoing architecture changes under physiological conditions. Such shape changing scaffolds show promise for regenerative medicine applications, but it remains unknown whether shape memory actuated changes in 3D architecture have detrimental effect on the differentiation capacity of stem cells resident in the scaffold during the change. In this study, we investigated the effect of architectural changes in 3D foams and fiber mats on the osteogenic capacity of human adipose-derived stem cells. The results demonstrate osteogenic capacity to be preserved following shape memory triggering, with no reduction in osteogenesis compared to a static control.

Original language	English (US)
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117135
State	Published - Jun 2 2015
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Other

Other	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country	United States
City	Troy
Period	4/17/15 → 4/19/15

ASJC Scopus subject areas

Biotechnology
Cancer Research
Cell Biology
Molecular Medicine
Biomedical Engineering
Control and Systems Engineering

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Preservation of osteogenic capacity following shape memory triggering of foam and e-spun scaffolds. / Wang, J.; Tseng, L. F.; Baker, R. M.; Henderson, James H.

2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117135.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wang, J, Tseng, LF, Baker, RM & Henderson, JH 2015, Preservation of osteogenic capacity following shape memory triggering of foam and e-spun scaffolds. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117135, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117135

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abstract = "Shape memory polymers (SMPs) have received significant attention for their potential to be applied in the development of dynamic, functional scaffolds for tissue engineering and regenerative medicine. Recent work has employed shape memory polymers in the development of topography-changing substrates, and these studies have shown that changes in topography can direct cell alignment, cell migration, and stem cell lineage commitment. Additional efforts have focused on expanding these strategies to 3D scaffolds that are capable of undergoing architecture changes under physiological conditions. Such shape changing scaffolds show promise for regenerative medicine applications, but it remains unknown whether shape memory actuated changes in 3D architecture have detrimental effect on the differentiation capacity of stem cells resident in the scaffold during the change. In this study, we investigated the effect of architectural changes in 3D foams and fiber mats on the osteogenic capacity of human adipose-derived stem cells. The results demonstrate osteogenic capacity to be preserved following shape memory triggering, with no reduction in osteogenesis compared to a static control.",

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AB - Shape memory polymers (SMPs) have received significant attention for their potential to be applied in the development of dynamic, functional scaffolds for tissue engineering and regenerative medicine. Recent work has employed shape memory polymers in the development of topography-changing substrates, and these studies have shown that changes in topography can direct cell alignment, cell migration, and stem cell lineage commitment. Additional efforts have focused on expanding these strategies to 3D scaffolds that are capable of undergoing architecture changes under physiological conditions. Such shape changing scaffolds show promise for regenerative medicine applications, but it remains unknown whether shape memory actuated changes in 3D architecture have detrimental effect on the differentiation capacity of stem cells resident in the scaffold during the change. In this study, we investigated the effect of architectural changes in 3D foams and fiber mats on the osteogenic capacity of human adipose-derived stem cells. The results demonstrate osteogenic capacity to be preserved following shape memory triggering, with no reduction in osteogenesis compared to a static control.

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Preservation of osteogenic capacity following shape memory triggering of foam and e-spun scaffolds

Abstract

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