Abstract
A practical, operationally simple preparation of 2-(trimethylsilyl)methyl-2-propen-1-ol derivatives is described. The cobalt catalyzed coupling of a protected vinyl halide with trimethylsilylmethylmagnesium chloride shows excellent functional group tolerance and provides these synthetically useful allyl silanes in good overall yield. By this method, the use of highly concentrated organolithium reagents, complex reaction protocols, and expensive starting materials is avoided.
Original language | English (US) |
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Pages (from-to) | 2809-2812 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 59 |
Issue number | 29 |
DOIs | |
State | Published - Jul 18 2018 |
Keywords
- Allylsilane
- Co catalyst
- Sp2-sp3 coupling
- Trimethylenemethane precursors
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry