Preferential mineralized tissue formation on materials with patterned surface chemistry

C. H. Thomas, C. D. McFarland, J. L. Gilbert, K. E. Healy

Research output: Contribution to conferencePaper

Abstract

The effects of substrate surface chemistry and bone cell organization on the formation of mineralized tissue in vitro on biomaterials were investigated. Mechanisms responsible for cell organization and subsequent mineralization were investigated using sera depleted of vitronectin, fibronectin or both. Exposure of bone cells to N-(2-aminoethyl)-3-aminopropyl-trimethoxysilane (EDS) and dimethyldichlorosilane (DMS) patterned surfaces resulted in mineralized tissue formation preferentially on the EDS regions. The absence of fibronectin had no effect on the attachment of bone cells exposed to the EDS/DMS patterned surfaces. The presence of vitronectin, when serum is included, was required for bone cell attachment, organization and subsequent mineralization.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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    Thomas, C. H., McFarland, C. D., Gilbert, J. L., & Healy, K. E. (1996). Preferential mineralized tissue formation on materials with patterned surface chemistry. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .