Abstract
The effects of substrate surface chemistry and bone cell organization on the formation of mineralized tissue in vitro on biomaterials were investigated. Mechanisms responsible for cell organization and subsequent mineralization were investigated using sera depleted of vitronectin, fibronectin or both. Exposure of bone cells to N-(2-aminoethyl)-3-aminopropyl-trimethoxysilane (EDS) and dimethyldichlorosilane (DMS) patterned surfaces resulted in mineralized tissue formation preferentially on the EDS regions. The absence of fibronectin had no effect on the attachment of bone cells exposed to the EDS/DMS patterned surfaces. The presence of vitronectin, when serum is included, was required for bone cell attachment, organization and subsequent mineralization.
Original language | English (US) |
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Pages | 946 |
Number of pages | 1 |
State | Published - 1996 |
Event | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996 |
Other
Other | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) |
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City | Toronto, Can |
Period | 5/29/96 → 6/2/96 |
ASJC Scopus subject areas
- General Materials Science