Posttraining brain norepinephrine concentrations: Correlation with retention performance of avoidance training and with peripheral epinephrine modulation of memory processing

Paul E. Gold, Roderick van Buskirk

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Posttrial epinephrine injections can enhance or impair later retention performance of inhibitory (passive) avoidance training in rats. The findings reported here indicate that the effects on retention of epinephrine injections and of footshock level are closely related to transient posttraining decreases in whole brain norepinephrine concentrations. Posttraining norepinephrine levels, as measured 10 min after training and treatment, predict the later retention performance of groups of rats trained with high or low footshock and, in addition, predict the retroactive effects (enhancement or impairment) of posttrial epinephrine injections. These findings are consistent with the view that hormonal responses to training may modulate memory storage processing. In addition, the results suggest that memory modulation may involve neuroendocrine mechanisms that include the central noradrenergic system.

Original languageEnglish (US)
Pages (from-to)509-520
Number of pages12
JournalBehavioral Biology
Volume23
Issue number4
DOIs
StatePublished - Aug 1978
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Science(all)
  • Earth and Planetary Sciences(all)

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