Poly(caprolactone) shape memory scaffold for bone tissue engineering

R. M. Baker, J. H. Henderson, P. T. Mather

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Using synthetic scaffolds as a vessel for bone tissue engineering is a promising technique that could address current limitations associated with autologous grafts, such as donor site scarcity and morbidity. In this study, we aimed to synthesize a biocompatible scaffold with controllable pore morphology that could be used to fill critical size defects through the shape memory effect. To achieve this goal we used a porogen-leaching technique in which a shape memory poly(caprolactone) (PCL) was cured in the presence of salt particles, which were subsequently removed to create high porosity in the scaffold. The overall shape memory behavior of the scaffold was investigated and it was found that the material exhibited greater than 99 % shape fixing and 93 % shape recovery. Preliminary cell culture studies on a non-triggered scaffold showed that cells readily attached to the material and remained viable within the scaffold.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages309-310
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Baker, R. M., Henderson, J. H., & Mather, P. T. (2012). Poly(caprolactone) shape memory scaffold for bone tissue engineering. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 309-310). [6207088] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6207088