Polyadenylylation in copia requires unusually distant upstream sequences

M. Kurkulos, J. M. Weinberg, M. E. Pepling, S. M. Mount

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Retroviruses and related genetic elements generate terminally redundant RNA products by differential polyadenylylation within a long terminal repeat. Expression of the white-apricot (wa) allele of Drosophila melanogaster, which carries an insertion of the 5.1-kilobase retrovirus-like transposable element copia in a small intron, is influenced by signals within copia. By using this indicator, we have isolated a 518-base-pair deletion, 312 base pairs upstream of the copia polyadenylylation site, that is phenotypically like much larger deletions and eliminates RNA species polyadenylylated in copia. This requirement of distant upstream sequences for copia polyadenylylation has implications for the expression of many genetic elements bearing long terminal repeats.

Original languageEnglish (US)
Pages (from-to)3038-3042
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number8
StatePublished - 1991
Externally publishedYes


  • Drosophila
  • long terminal repeat
  • retrotransposon
  • white-apricot

ASJC Scopus subject areas

  • General


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