PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo

Lindsay I. Rathbun, Abrar A. Aljiboury, Xiaofei Bai, Nicole A. Hall, Julie Manikas, Jeffrey D. Amack, Joshua N. Bembenek, Heidi Hehnly

Research output: Contribution to journalArticlepeer-review

Abstract

During embryonic cell divisions, cell size changes rapidly. Rathbun et al. identify in zebrafish embryos that mitotic centrosomes scale with changes in cell size. In addition, an embryonic cell spindle has asymmetric in size mitotic centrosomes, where the largest mitotic centrosome is placed toward the embryo center in a PLK1/4-dependent manner.

Original languageEnglish (US)
Pages (from-to)4519-4527.e3
JournalCurrent Biology
Volume30
Issue number22
DOIs
StatePublished - Nov 16 2020

Keywords

  • C. elegans
  • PCM
  • PLK1
  • PLK4
  • centrosome
  • embryo
  • microtubules
  • mitosis
  • spindle
  • zebrafish

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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