@article{b3cda76ea8a545faaafe85125ace1c69,
title = "PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo",
abstract = "During embryonic cell divisions, cell size changes rapidly. Rathbun et al. identify in zebrafish embryos that mitotic centrosomes scale with changes in cell size. In addition, an embryonic cell spindle has asymmetric in size mitotic centrosomes, where the largest mitotic centrosome is placed toward the embryo center in a PLK1/4-dependent manner.",
keywords = "C. elegans, PCM, PLK1, PLK4, centrosome, embryo, microtubules, mitosis, spindle, zebrafish",
author = "Rathbun, {Lindsay I.} and Aljiboury, {Abrar A.} and Xiaofei Bai and Hall, {Nicole A.} and Julie Manikas and Amack, {Jeffrey D.} and Bembenek, {Joshua N.} and Heidi Hehnly",
note = "Funding Information: We thank Lilianna Solnica-Krezel (UW) for sharing the ?actin::centrin-GFP zebrafish line. This work was supported by National Institutes of Health grants R00GM107355, R01GM127621 (to H.H.), and R01GM114471 (to J.N.B.), and a Syracuse University ?Cuse Good-to-Great award. We thank the Caenorhabditis Genetics Center, which is funded by National Institutes of Health Office of Research Infrastructure Programs (P40OD010440), for providing strains for this study. L.I.R. designed, performed, and analyzed experiments, and wrote the manuscript; H.H. oversaw the project and edited and wrote the manuscript; J.N.B. edited the manuscript and advised on C. elegans studies; J.D.A. edited the manuscript and provided zebrafish expertise; and A.A.A. J.M. X.B. and N.A.H. performed experiments and associated analyses and edited the manuscript. The authors declare no competing interests. Funding Information: We thank Lilianna Solnica-Krezel (UW) for sharing the βactin::centrin-GFP zebrafish line. This work was supported by National Institutes of Health grants R00GM107355 , R01GM127621 (to H.H.), and R01GM114471 (to J.N.B.), and a Syracuse University {\textquoteleft}Cuse Good-to-Great award. We thank the Caenorhabditis Genetics Center, which is funded by National Institutes of Health Office of Research Infrastructure Programs ( P40OD010440 ), for providing strains for this study. ",
year = "2020",
month = nov,
day = "16",
doi = "10.1016/j.cub.2020.08.074",
language = "English (US)",
volume = "30",
pages = "4519--4527.e3",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "22",
}