Plasma prekallikrein levels are positively associated with circulating lipid levels and the metabolic syndrome in children

James A. MacKenzie, Kristen A. Roosa, Brooks B. Gump, Amy K. Dumas, Kestutis G. Bendinskas

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Plasma prekallikrein (PK) has been shown to be associated with cardiovascular disease (CVD) and its risk factors, but these associations have not been investigated in children. The present study examined PK activity in relation to well-established cardiovascular risk factors in a cohort of children aged 9-11 years (N = 97). We found a significant and positive association between PK and fasting levels of total cholesterol (p < 0.01), non-high-density lipoprotein cholesterol (p < 0.01), and triglycerides (p < 0.001). In addition, there was a significant association between PK activity and the metabolic syndrome, a clustering of risk factors considered to have an impact on atherosclerosis and CVD mortality. Finally, we found that children with a family history of CVD had significantly elevated PK activity. These novel findings warrant further investigations into the relationship between circulating PK levels and CVD risk factors because PK may be involved in the progression of the disease state.

Original languageEnglish (US)
Pages (from-to)518-525
Number of pages8
JournalApplied Physiology, Nutrition and Metabolism
Volume35
Issue number4
DOIs
StatePublished - Oct 26 2010

Keywords

  • Cardiovascular disease
  • Children
  • Lipids
  • Metabolic syndrome
  • Plasma
  • Prekallikrein

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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