Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation

Ayhan Korkmaz, Mika Venojärvi, Niko Wasenius, Sirpa Manderoos, Keith C Deruisseau, Eva Karin Gidlund, Olli J. Heinonen, Harri Lindholm, Sirkka Aunola, Johan G. Eriksson, Mustafa Atalay

Research output: Contribution to journalArticle

Abstract

Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n = 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n = 105) and skeletal muscle samples (n = 45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6 ± 4.2%, P= 0.014; 8.7 ± 4.9%, P= 0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r= 0.244, P= 0.013) and 2-hour insulin levels (r = 0.214, P= 0.028), and negatively with age (r = −0.262, P= 0.007), adiponectin (r = −0.240, P= 0.014) and McAuley index (r = −0.259, P= 0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r= −0.527, P= 0.030) in the resistance training group and with chemerin in the Nordic walking group (r = −0.615, P = 0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.

Original languageEnglish (US)
JournalEuropean Journal of Sport Science
DOIs
StateAccepted/In press - Jan 1 2018

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Walking
Homeostasis
Exercise
Resistance Training
Glucose
Glucose Intolerance
Adiponectin
Skeletal Muscle
Obesity
Insulin
Messenger RNA

Keywords

  • metabolism
  • obesity
  • Training

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation. / Korkmaz, Ayhan; Venojärvi, Mika; Wasenius, Niko; Manderoos, Sirpa; Deruisseau, Keith C; Gidlund, Eva Karin; Heinonen, Olli J.; Lindholm, Harri; Aunola, Sirkka; Eriksson, Johan G.; Atalay, Mustafa.

In: European Journal of Sport Science, 01.01.2018.

Research output: Contribution to journalArticle

Korkmaz, Ayhan ; Venojärvi, Mika ; Wasenius, Niko ; Manderoos, Sirpa ; Deruisseau, Keith C ; Gidlund, Eva Karin ; Heinonen, Olli J. ; Lindholm, Harri ; Aunola, Sirkka ; Eriksson, Johan G. ; Atalay, Mustafa. / Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation. In: European Journal of Sport Science. 2018.
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abstract = "Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n = 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n = 105) and skeletal muscle samples (n = 45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6 ± 4.2{\%}, P= 0.014; 8.7 ± 4.9{\%}, P= 0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r= 0.244, P= 0.013) and 2-hour insulin levels (r = 0.214, P= 0.028), and negatively with age (r = −0.262, P= 0.007), adiponectin (r = −0.240, P= 0.014) and McAuley index (r = −0.259, P= 0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r= −0.527, P= 0.030) in the resistance training group and with chemerin in the Nordic walking group (r = −0.615, P = 0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.",
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AU - Deruisseau, Keith C

AU - Gidlund, Eva Karin

AU - Heinonen, Olli J.

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AU - Aunola, Sirkka

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AU - Atalay, Mustafa

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