TY - JOUR
T1 - Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation
AU - Korkmaz, Ayhan
AU - Venojärvi, Mika
AU - Wasenius, Niko
AU - Manderoos, Sirpa
AU - Deruisseau, Keith C
AU - Gidlund, Eva Karin
AU - Heinonen, Olli J.
AU - Lindholm, Harri
AU - Aunola, Sirkka
AU - Eriksson, Johan G.
AU - Atalay, Mustafa
N1 - Publisher Copyright:
© 2018, © 2018 European College of Sport Science.
PY - 2019/2/7
Y1 - 2019/2/7
N2 - Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n = 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n = 105) and skeletal muscle samples (n = 45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6 ± 4.2%, P= 0.014; 8.7 ± 4.9%, P= 0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r= 0.244, P= 0.013) and 2-hour insulin levels (r = 0.214, P= 0.028), and negatively with age (r = −0.262, P= 0.007), adiponectin (r = −0.240, P= 0.014) and McAuley index (r = −0.259, P= 0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r= −0.527, P= 0.030) in the resistance training group and with chemerin in the Nordic walking group (r = −0.615, P = 0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.
AB - Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n = 144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n = 105) and skeletal muscle samples (n = 45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6 ± 4.2%, P= 0.014; 8.7 ± 4.9%, P= 0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r= 0.244, P= 0.013) and 2-hour insulin levels (r = 0.214, P= 0.028), and negatively with age (r = −0.262, P= 0.007), adiponectin (r = −0.240, P= 0.014) and McAuley index (r = −0.259, P= 0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r= −0.527, P= 0.030) in the resistance training group and with chemerin in the Nordic walking group (r = −0.615, P = 0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.
KW - Training
KW - metabolism
KW - obesity
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U2 - 10.1080/17461391.2018.1506504
DO - 10.1080/17461391.2018.1506504
M3 - Article
C2 - 30132382
AN - SCOPUS:85052338423
SN - 1746-1391
VL - 19
SP - 258
EP - 266
JO - European Journal of Sport Science
JF - European Journal of Sport Science
IS - 2
ER -