Photoswitchable TCB-2 for control of the 5-HT2A receptor and analysis of biased agonism

Alireza Jafar Esmaeili, Pantea Montazeri, Jasmine Cristina Gomez, Didier J. Dumervil, Faezeh Safar Nezhad, Rachel C. Steinhardt

Research output: Contribution to journalArticlepeer-review

Abstract

Therapies that target the serotonin 2A receptor (5-HT2AR) are promising. However, probes are needed to better understand the role of 5-HT2AR. Here, we design and synthesize a photoswitch and photoswitchable 5-HT2AR ligand based on highly potent agonist TCB-2 and arylazopyrazole, which also boasts photoswitchable G protein vs. β-arrestin pathway bias.

Original languageEnglish (US)
Pages (from-to)11956-11959
Number of pages4
JournalChemical Communications
Volume60
Issue number83
DOIs
StatePublished - Sep 25 2024

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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