Abstract
Therapies that target the serotonin 2A receptor (5-HT2AR) are promising. However, probes are needed to better understand the role of 5-HT2AR. Here, we design and synthesize a photoswitch and photoswitchable 5-HT2AR ligand based on highly potent agonist TCB-2 and arylazopyrazole, which also boasts photoswitchable G protein vs. β-arrestin pathway bias.
Original language | English (US) |
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Pages (from-to) | 11956-11959 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 60 |
Issue number | 83 |
DOIs | |
State | Published - Sep 25 2024 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Catalysis
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry