Phosphine-catalyzed nitroaldol reactions

Jason A. Weeden, John D. Chisholm

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Trialkyl phosphines and electron-rich triaryl phosphines are excellent catalysts for the nitroaldol (Henry) reaction. Aryl and alkyl aldehydes participate well in the reaction with nitromethane providing good yields of product. Care should be exercised in the use of phosphine-metal complexes as catalysts for the nitroaldol reaction, as the phosphine can alone function as the catalyst.

Original languageEnglish (US)
Pages (from-to)9313-9316
Number of pages4
JournalTetrahedron Letters
Issue number52
StatePublished - Dec 25 2006

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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