Peripheral Vascular Endothelial Function in Patients With Hypertrophic Cardiomyopathy

Kevin S. Heffernan, Craig A. Napolitano, Martin S. Maron, Eshan A. Patvardhan, Ayan R. Patel, Natesa G. Pandian, Richard H. Karas, Jeffrey T. Kuvin

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Patients with hypertrophic cardiomyopathy (HC) have coronary microvascular dysfunction, which is an independent predictor of adverse left ventricular remodeling, systolic dysfunction, and mortality in these patients. Whether these defects in vasomotor function are localized to the coronary arteries or whether systemic vasomotor dysfunction is present in patients with HC has not yet been adequately examined. The aim of this study was to test the hypothesis that patients with HC have altered peripheral vascular endothelial function. Subjects without coronary artery disease (CAD) and those with CAD served as negative and positive controls, respectively. Conduit artery endothelium-dependent vasomotion was assessed with ultrasound by measuring flow-mediated dilation of the brachial artery. Flow-mediated dilation was lower in patients with HC compared with those without CAD (p <0.05) but was similar in patients with CAD (p = NS). In conclusion, vasomotor dysfunction in HC is not restricted to the coronary vasculature. Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD.

Original languageEnglish (US)
Pages (from-to)112-115
Number of pages4
JournalAmerican Journal of Cardiology
Volume105
Issue number1
DOIs
StatePublished - Jan 1 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Heffernan, K. S., Napolitano, C. A., Maron, M. S., Patvardhan, E. A., Patel, A. R., Pandian, N. G., Karas, R. H., & Kuvin, J. T. (2010). Peripheral Vascular Endothelial Function in Patients With Hypertrophic Cardiomyopathy. American Journal of Cardiology, 105(1), 112-115. https://doi.org/10.1016/j.amjcard.2009.08.658