Peripheral catecholamines and memory: Characteristics of syrosingopine-induced amnesia

Thomas J. Walsh; Tibor Palfai

doi:10.1016/0091-3057(79)90123-0

Peripheral catecholamines and memory: Characteristics of syrosingopine-induced amnesia

Thomas J. Walsh, Tibor Palfai

Department of Psychology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr before or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.

Original language	English (US)
Pages (from-to)	449-452
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(79)90123-0
State	Published - Oct 1979

Keywords

Amnesia
Catecholamines
Memory
Passive avoidance
Rauwolfia alkaloids

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(79)90123-0

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abstract = "The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr before or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.",

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AB - The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr before or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.

KW - Amnesia

KW - Catecholamines

KW - Memory

KW - Passive avoidance

KW - Rauwolfia alkaloids

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Peripheral catecholamines and memory: Characteristics of syrosingopine-induced amnesia

Abstract

Keywords

ASJC Scopus subject areas

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