Peripheral catecholamines and memory: Characteristics of syrosingopine-induced amnesia

Thomas J. Walsh, Tibor Palfai

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr before or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.

Original languageEnglish (US)
Pages (from-to)449-452
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume11
Issue number4
DOIs
StatePublished - 1979

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Keywords

  • Amnesia
  • Catecholamines
  • Memory
  • Passive avoidance
  • Rauwolfia alkaloids

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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