Peptide hydrogel with self-healing and redox-responsive properties

Areetha D’Souza; Liam R. Marshall; Jennifer Yoon; Alona Kulesha; Dona I.U. Edirisinghe; Siddarth Chandrasekaran; Parth Rathee; Rajeev Prabhakar; Olga V. Makhlynets

doi:10.1186/s40580-022-00309-7

Peptide hydrogel with self-healing and redox-responsive properties

Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I.U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

Original language	English (US)
Article number	18
Journal	Nano Convergence
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s40580-022-00309-7
State	Published - Dec 2022

Keywords

Antimicrobial wound dressing
Copper reduction
Hydrogel
Self-healing and redox-responsive properties

ASJC Scopus subject areas

General Materials Science
General Engineering

Access to Document

10.1186/s40580-022-00309-7

Cite this

@article{4bae3363ebe341a1840ad7df7a433b62,

title = "Peptide hydrogel with self-healing and redox-responsive properties",

abstract = "We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.",

keywords = "Antimicrobial wound dressing, Copper reduction, Hydrogel, Self-healing and redox-responsive properties",

author = "Areetha D{\textquoteright}Souza and Marshall, {Liam R.} and Jennifer Yoon and Alona Kulesha and Edirisinghe, {Dona I.U.} and Siddarth Chandrasekaran and Parth Rathee and Rajeev Prabhakar and Makhlynets, {Olga V.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1186/s40580-022-00309-7",

language = "English (US)",

volume = "9",

journal = "Nano Convergence",

issn = "2196-5404",

publisher = "SpringerOpen",

number = "1",

}

TY - JOUR

T1 - Peptide hydrogel with self-healing and redox-responsive properties

AU - D’Souza, Areetha

AU - Marshall, Liam R.

AU - Yoon, Jennifer

AU - Kulesha, Alona

AU - Edirisinghe, Dona I.U.

AU - Chandrasekaran, Siddarth

AU - Rathee, Parth

AU - Prabhakar, Rajeev

AU - Makhlynets, Olga V.

PY - 2022/12

Y1 - 2022/12

N2 - We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

AB - We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

KW - Antimicrobial wound dressing

KW - Copper reduction

KW - Hydrogel

KW - Self-healing and redox-responsive properties

UR - http://www.scopus.com/inward/record.url?scp=85128910057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85128910057&partnerID=8YFLogxK

U2 - 10.1186/s40580-022-00309-7

DO - 10.1186/s40580-022-00309-7

M3 - Article

AN - SCOPUS:85128910057

SN - 2196-5404

VL - 9

JO - Nano Convergence

JF - Nano Convergence

IS - 1

M1 - 18

ER -

Peptide hydrogel with self-healing and redox-responsive properties

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this