Peptide hydrogel with self-healing and redox-responsive properties

Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I.U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets

Research output: Contribution to journalArticlepeer-review

Abstract

We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.

Original languageEnglish (US)
Article number18
JournalNano Convergence
Volume9
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Antimicrobial wound dressing
  • Copper reduction
  • Hydrogel
  • Self-healing and redox-responsive properties

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)

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