Pentylenetetrazol-induced amnesia: a case for overt seizures

Tibor Palfai, Bruce Albala

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In this study, the possible role of overt convulsions following pentylenetetrazol (PTZ) in retrograde amnesia was investigated. Following a single passive avoidance conditioning, when overt convulsions were blocked with sodium pentobarbital (Nem), the amnesic effect of pentylenetetrazol was also blocked. Subconvulsive doses of the drug did not produce amnesia. Animals that received a typically convulsive dose of the drug but failed to convulse were not amnesic; only animals with overt convulsions were different from saline controls. The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalPsychopharmacology
Volume48
Issue number1
DOIs
StatePublished - Jan 1 1976

Keywords

  • Convulsions
  • Metrazol
  • Mice
  • Passive avoidance
  • Pentylenetetrazol
  • Retrograde amnesia
  • Strain differences

ASJC Scopus subject areas

  • Pharmacology

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