Pentylenetetrazol-induced amnesia: a case for overt seizures

Tibor Palfai, Bruce Albala

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In this study, the possible role of overt convulsions following pentylenetetrazol (PTZ) in retrograde amnesia was investigated. Following a single passive avoidance conditioning, when overt convulsions were blocked with sodium pentobarbital (Nem), the amnesic effect of pentylenetetrazol was also blocked. Subconvulsive doses of the drug did not produce amnesia. Animals that received a typically convulsive dose of the drug but failed to convulse were not amnesic; only animals with overt convulsions were different from saline controls. The data suggest that overt convulsions may be necessary for the development of pentylenetetrazol-induced retrograde amnesia.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
Issue number1
StatePublished - Jan 1976


  • Convulsions
  • Metrazol
  • Mice
  • Passive avoidance
  • Pentylenetetrazol
  • Retrograde amnesia
  • Strain differences

ASJC Scopus subject areas

  • Pharmacology


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