Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms

Systematic review and meta-analysis

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Rationale: Certifications for medical cannabis are generally restricted to a small number of specific medical conditions, yet patients frequently report symptoms of pain, anxiety, and depression as reasons for use. This is a critical concern for researchers, healthcare providers, and policymakers, yet research in this area is currently obstructed by the lack of a focused review or empirical synthesis on patient-reported reasons for medical cannabis use. Objectives: AND METHOD: The first aim of this project was to conduct the first systematic review and meta-analysis of empirical studies of patient-reported symptoms of pain, anxiety, and depression as reasons for medical cannabis use. The second aim was to conduct an empirical assessment of the methodological quality of extant research, test for publication bias, and test sex composition and quality scores of individual studies as possible sources of observed heterogeneity. Results: Meta-analytic results indicated that pain (64%), anxiety (50%), and depression/mood (34%) were common reasons for medical cannabis use. No evidence for publication bias was detected, despite heterogeneity in prevalence rates. A comprehensive assessment of study quality identified a number of specific methodological limitations of the existing research, including challenges in patient recruitment, use of restrictive sampling frames, and a lack of randomized recruitment methods and validated assessment measures. Conclusion: Findings are discussed with regard to possible explanations for current results, clinical considerations, and areas of future research that are needed to move the field forward.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalSocial Science and Medicine
Volume233
DOIs
StatePublished - Jul 1 2019

Fingerprint

Medical Marijuana
Meta-Analysis
pain
Anxiety
Depression
anxiety
Pain
Publication Bias
lack
Research
trend
mood
certification
Certification
Health Personnel
Patient Selection
Research Personnel
evidence
Meta-analysis
Systematic Review

Keywords

  • Anxiety
  • Chronic pain
  • Depression
  • Marijuana
  • Medical cannabis
  • meta-Analysis
  • Pain
  • Systematic review

ASJC Scopus subject areas

  • Health(social science)
  • History and Philosophy of Science

Cite this

@article{09367e2e6cc14b63901ddfe2874a4b4a,
title = "Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms: Systematic review and meta-analysis",
abstract = "Rationale: Certifications for medical cannabis are generally restricted to a small number of specific medical conditions, yet patients frequently report symptoms of pain, anxiety, and depression as reasons for use. This is a critical concern for researchers, healthcare providers, and policymakers, yet research in this area is currently obstructed by the lack of a focused review or empirical synthesis on patient-reported reasons for medical cannabis use. Objectives: AND METHOD: The first aim of this project was to conduct the first systematic review and meta-analysis of empirical studies of patient-reported symptoms of pain, anxiety, and depression as reasons for medical cannabis use. The second aim was to conduct an empirical assessment of the methodological quality of extant research, test for publication bias, and test sex composition and quality scores of individual studies as possible sources of observed heterogeneity. Results: Meta-analytic results indicated that pain (64{\%}), anxiety (50{\%}), and depression/mood (34{\%}) were common reasons for medical cannabis use. No evidence for publication bias was detected, despite heterogeneity in prevalence rates. A comprehensive assessment of study quality identified a number of specific methodological limitations of the existing research, including challenges in patient recruitment, use of restrictive sampling frames, and a lack of randomized recruitment methods and validated assessment measures. Conclusion: Findings are discussed with regard to possible explanations for current results, clinical considerations, and areas of future research that are needed to move the field forward.",
keywords = "Anxiety, Chronic pain, Depression, Marijuana, Medical cannabis, meta-Analysis, Pain, Systematic review",
author = "Kosiba, {Jesse D.} and Maisto, {Stephen A} and Ditre, {Joseph W}",
year = "2019",
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doi = "10.1016/j.socscimed.2019.06.005",
language = "English (US)",
volume = "233",
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journal = "Social Science and Medicine",
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T1 - Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms

T2 - Systematic review and meta-analysis

AU - Kosiba, Jesse D.

AU - Maisto, Stephen A

AU - Ditre, Joseph W

PY - 2019/7/1

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N2 - Rationale: Certifications for medical cannabis are generally restricted to a small number of specific medical conditions, yet patients frequently report symptoms of pain, anxiety, and depression as reasons for use. This is a critical concern for researchers, healthcare providers, and policymakers, yet research in this area is currently obstructed by the lack of a focused review or empirical synthesis on patient-reported reasons for medical cannabis use. Objectives: AND METHOD: The first aim of this project was to conduct the first systematic review and meta-analysis of empirical studies of patient-reported symptoms of pain, anxiety, and depression as reasons for medical cannabis use. The second aim was to conduct an empirical assessment of the methodological quality of extant research, test for publication bias, and test sex composition and quality scores of individual studies as possible sources of observed heterogeneity. Results: Meta-analytic results indicated that pain (64%), anxiety (50%), and depression/mood (34%) were common reasons for medical cannabis use. No evidence for publication bias was detected, despite heterogeneity in prevalence rates. A comprehensive assessment of study quality identified a number of specific methodological limitations of the existing research, including challenges in patient recruitment, use of restrictive sampling frames, and a lack of randomized recruitment methods and validated assessment measures. Conclusion: Findings are discussed with regard to possible explanations for current results, clinical considerations, and areas of future research that are needed to move the field forward.

AB - Rationale: Certifications for medical cannabis are generally restricted to a small number of specific medical conditions, yet patients frequently report symptoms of pain, anxiety, and depression as reasons for use. This is a critical concern for researchers, healthcare providers, and policymakers, yet research in this area is currently obstructed by the lack of a focused review or empirical synthesis on patient-reported reasons for medical cannabis use. Objectives: AND METHOD: The first aim of this project was to conduct the first systematic review and meta-analysis of empirical studies of patient-reported symptoms of pain, anxiety, and depression as reasons for medical cannabis use. The second aim was to conduct an empirical assessment of the methodological quality of extant research, test for publication bias, and test sex composition and quality scores of individual studies as possible sources of observed heterogeneity. Results: Meta-analytic results indicated that pain (64%), anxiety (50%), and depression/mood (34%) were common reasons for medical cannabis use. No evidence for publication bias was detected, despite heterogeneity in prevalence rates. A comprehensive assessment of study quality identified a number of specific methodological limitations of the existing research, including challenges in patient recruitment, use of restrictive sampling frames, and a lack of randomized recruitment methods and validated assessment measures. Conclusion: Findings are discussed with regard to possible explanations for current results, clinical considerations, and areas of future research that are needed to move the field forward.

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KW - Chronic pain

KW - Depression

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KW - meta-Analysis

KW - Pain

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