Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions

Yurii S. Moroz; Wolfgang Binder; Patrik Nygren; Gregory A. Caputo; Ivan V. Korendovych

doi:10.1039/c2cc37550h

Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions

Yurii S. Moroz, Wolfgang Binder, Patrik Nygren, Gregory A. Caputo, Ivan V. Korendovych

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We demonstrated that β-(1-azulenyl)-l-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.

Original language	English (US)
Pages (from-to)	490-492
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	5
DOIs	https://doi.org/10.1039/c2cc37550h
State	Published - 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc37550h

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title = "Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions",

abstract = "We demonstrated that β-(1-azulenyl)-l-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.",

author = "Moroz, {Yurii S.} and Wolfgang Binder and Patrik Nygren and Caputo, {Gregory A.} and Korendovych, {Ivan V.}",

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AU - Binder, Wolfgang

AU - Nygren, Patrik

AU - Caputo, Gregory A.

AU - Korendovych, Ivan V.

PY - 2013

Y1 - 2013

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AB - We demonstrated that β-(1-azulenyl)-l-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.

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AN - SCOPUS:84871276527

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JO - Chemical Communications

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Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions

Abstract

ASJC Scopus subject areas

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