Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions

Yurii S. Moroz, Wolfgang Binder, Patrik Nygren, Gregory A. Caputo, Ivan Korendovych

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We demonstrated that β-(1-azulenyl)-l-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.

Original languageEnglish (US)
Pages (from-to)490-492
Number of pages3
JournalChemical Communications
Volume49
Issue number5
DOIs
StatePublished - Jan 18 2013

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Painting
Alanine
Proteins
Tryptophan
Methionine

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Painting proteins blue : β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions. / Moroz, Yurii S.; Binder, Wolfgang; Nygren, Patrik; Caputo, Gregory A.; Korendovych, Ivan.

In: Chemical Communications, Vol. 49, No. 5, 18.01.2013, p. 490-492.

Research output: Contribution to journalArticle

Moroz, Yurii S. ; Binder, Wolfgang ; Nygren, Patrik ; Caputo, Gregory A. ; Korendovych, Ivan. / Painting proteins blue : β-(1-azulenyl)-l-alanine as a probe for studying protein-protein interactions. In: Chemical Communications. 2013 ; Vol. 49, No. 5. pp. 490-492.
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