Origins of the relative stabilities of anhydrous and hydrated D-mannitol crystals

Teresa M. Dierks, Timothy Michael Korter

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

D-Mannitol, a common bulking agent used in the pharmaceutical and food industries, is known to crystallize in three anhydrous polymorphs (α, β, and δ) and a hemihydrate form. In this work, solid-state density functional theory simulations and experimental terahertz spectroscopy were used to evaluate the stabilities, thermodynamic relationships, and spectral signatures of these various solids. The thermodynamic analyses of the anhydrous polymorphs identified enantiotropic transitions for β-δ at approximately room temperature and α-δ near the α melting point, but showed α and β to be monotropically related. Computational refinement of the D-mannitol hemihydrate crystal structure and comparison of its Gibbs free energy to the anhydrous forms showed the hemihydrate to be stable only at low temperatures (<253 K), in agreement with experiment, and reveals its conversion to the δ polymorph upon dehydration. Quantification of the intramolecular and intermolecular energies within these solids highlights the competition that exists between molecular conformation and cohesion energies and how a balance of these forces dictates the observed behaviors.

Original languageEnglish (US)
Pages (from-to)6629-6636
Number of pages8
JournalJournal of Physical Chemistry A
Volume120
Issue number33
DOIs
StatePublished - Aug 25 2016

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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