TY - JOUR
T1 - Origins of the relative stabilities of anhydrous and hydrated D-mannitol crystals
AU - Dierks, Teresa M.
AU - Korter, Timothy M.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/8/25
Y1 - 2016/8/25
N2 - D-Mannitol, a common bulking agent used in the pharmaceutical and food industries, is known to crystallize in three anhydrous polymorphs (α, β, and δ) and a hemihydrate form. In this work, solid-state density functional theory simulations and experimental terahertz spectroscopy were used to evaluate the stabilities, thermodynamic relationships, and spectral signatures of these various solids. The thermodynamic analyses of the anhydrous polymorphs identified enantiotropic transitions for β-δ at approximately room temperature and α-δ near the α melting point, but showed α and β to be monotropically related. Computational refinement of the D-mannitol hemihydrate crystal structure and comparison of its Gibbs free energy to the anhydrous forms showed the hemihydrate to be stable only at low temperatures (<253 K), in agreement with experiment, and reveals its conversion to the δ polymorph upon dehydration. Quantification of the intramolecular and intermolecular energies within these solids highlights the competition that exists between molecular conformation and cohesion energies and how a balance of these forces dictates the observed behaviors.
AB - D-Mannitol, a common bulking agent used in the pharmaceutical and food industries, is known to crystallize in three anhydrous polymorphs (α, β, and δ) and a hemihydrate form. In this work, solid-state density functional theory simulations and experimental terahertz spectroscopy were used to evaluate the stabilities, thermodynamic relationships, and spectral signatures of these various solids. The thermodynamic analyses of the anhydrous polymorphs identified enantiotropic transitions for β-δ at approximately room temperature and α-δ near the α melting point, but showed α and β to be monotropically related. Computational refinement of the D-mannitol hemihydrate crystal structure and comparison of its Gibbs free energy to the anhydrous forms showed the hemihydrate to be stable only at low temperatures (<253 K), in agreement with experiment, and reveals its conversion to the δ polymorph upon dehydration. Quantification of the intramolecular and intermolecular energies within these solids highlights the competition that exists between molecular conformation and cohesion energies and how a balance of these forces dictates the observed behaviors.
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U2 - 10.1021/acs.jpca.6b05244
DO - 10.1021/acs.jpca.6b05244
M3 - Article
C2 - 27463148
AN - SCOPUS:84983651670
SN - 1089-5639
VL - 120
SP - 6629
EP - 6636
JO - Journal of Physical Chemistry A
JF - Journal of Physical Chemistry A
IS - 33
ER -