Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Chun Ting Chen, Heidi Hehnly, Stephen J. Doxsey

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalNature Reviews Molecular Cell Biology
Issue number8
StatePublished - Aug 2012
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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