Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Chun Ting Chen; Heidi Hehnly; Stephen J. Doxsey

doi:10.1038/nrm3395

Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Chun Ting Chen, Heidi Hehnly, Stephen J. Doxsey

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.

Original language	English (US)
Pages (from-to)	483-488
Number of pages	6
Journal	Nature Reviews Molecular Cell Biology
Volume	13
Issue number	8
DOIs	https://doi.org/10.1038/nrm3395
State	Published - Aug 2012
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission",

abstract = "During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.",

author = "Chen, {Chun Ting} and Heidi Hehnly and Doxsey, {Stephen J.}",

note = "Funding Information: The authors apologize to colleagues whose work is not discussed or cited owing to space constraints. The authors are particularly grateful to A. Bright and S. Redick from the Doxsey laboratory for critical reading of the manuscript and thoughtful discussions. Work in the Doxsey laboratory is supported by the US National Institutes of Health (NIH), the Ellison Medical Foundation, the W. M. Keck Foundation and the US Department of Defense.",

year = "2012",

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doi = "10.1038/nrm3395",

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AU - Chen, Chun Ting

AU - Hehnly, Heidi

AU - Doxsey, Stephen J.

N1 - Funding Information: The authors apologize to colleagues whose work is not discussed or cited owing to space constraints. The authors are particularly grateful to A. Bright and S. Redick from the Doxsey laboratory for critical reading of the manuscript and thoughtful discussions. Work in the Doxsey laboratory is supported by the US National Institutes of Health (NIH), the Ellison Medical Foundation, the W. M. Keck Foundation and the US Department of Defense.

PY - 2012/8

Y1 - 2012/8

N2 - During the final stage of cell division, the future daughter cells are physically separated through abscission. This process requires coordination of many molecular machines, including endocytic and secretory vesicle trafficking proteins as well as ESCRT (endosomal sorting complex required for transport) proteins, that mediate a complex series of events to culminate in the final separation of daughter cells. Abscission is coordinated with other cellular processes (for example, nuclear pore reassembly) through mitotic kinases such as Aurora B and Polo-like kinase 1, which act as master regulators to ensure proper progression of abscission.

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Orchestrating vesicle transport, ESCRTs and kinase surveillance during abscission

Abstract

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