Oral exposure to polystyrene nanoparticles affects iron absorption

Gretchen J. Mahler, Mandy B. Esch, Elad Tako, Teresa L. Southard, Shivaun D. Archer, Raymond P. Glahn, Michael L. Shuler

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

The use of engineered nanoparticles in food and pharmaceuticals is expected to increase, but the impact of chronic oral exposure to nanoparticles on human health remains unknown. Here, we show that chronic and acute oral exposure to polystyrene nanoparticles can influence iron uptake and iron transport in an in vitro model of the intestinal epithelium and an in vivo chicken intestinal loop model. Intestinal cells that are exposed to high doses of nanoparticles showed increased iron transport due to nanoparticle disruption of the cell membrane. Chickens acutely exposed to carboxylated particles (50 nm in diameter) had a lower iron absorption than unexposed or chronically exposed birds. Chronic exposure caused remodelling of the intestinal villi, which increased the surface area available for iron absorption. The agreement between the in vitro and in vivo results suggests that our in vitro intestinal epithelium model is potentially useful for toxicology studies.

Original languageEnglish (US)
Pages (from-to)264-271
Number of pages8
JournalNature Nanotechnology
Volume7
Issue number4
DOIs
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Mahler, G. J., Esch, M. B., Tako, E., Southard, T. L., Archer, S. D., Glahn, R. P., & Shuler, M. L. (2012). Oral exposure to polystyrene nanoparticles affects iron absorption. Nature Nanotechnology, 7(4), 264-271. https://doi.org/10.1038/nnano.2012.3