Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Christopher H. Fazen; Debbie Valentin; Timothy J. Fairchild; Robert P. Doyle

doi:10.1021/jm2012547

Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B ₁₂ uptake pathway

Christopher H. Fazen, Debbie Valentin, Timothy J. Fairchild, Robert P. Doyle

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B ₁₂ pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B ₁₂-hPYY(3-36) conjugates.

Original language	English (US)
Pages (from-to)	8707-8711
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	24
DOIs	https://doi.org/10.1021/jm2012547
State	Published - Dec 22 2011

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm2012547

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abstract = "hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B 12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B 12-hPYY(3-36) conjugates.",

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AU - Fairchild, Timothy J.

AU - Doyle, Robert P.

PY - 2011/12/22

Y1 - 2011/12/22

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AB - hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B 12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B 12-hPYY(3-36) conjugates.

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Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B ₁₂ uptake pathway

Abstract

ASJC Scopus subject areas

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