Oral delivery of the appetite suppressing peptide hPYY(3-36) through the Vitamin B 12 uptake pathway

Christopher H. Fazen, Debbie Valentin, Timothy J. Fairchild, Robert P. Doyle

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

hPYY(3-36) injections have shown positive effects on appetite regulations, sparking increased interest in hPYY(3-36) research. Of great interest is oral delivery of hPYY(3-36) that can achieve clinically relevant weight-loss outcomes in what would be a highly patient compliant route. Successful oral delivery of other peptides utilizing the vitamin B 12 pathway has been shown but below clinically relevant levels. Herein, we present clinically relevant in vivo oral delivery of B 12-hPYY(3-36) conjugates.

Original languageEnglish (US)
Pages (from-to)8707-8711
Number of pages5
JournalJournal of Medicinal Chemistry
Volume54
Issue number24
DOIs
StatePublished - Dec 22 2011

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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