Onset-offset cortical auditory evoked potential amplitude differences indicate auditory cortical hyperactivity and reduced inhibition in people with tinnitus

Kenneth Morse, Kathy R. Vander Werff

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The current study investigates evidence of hypothesized reduced central inhibition and/or increased excitation in individuals with tinnitus by evaluating cortical auditory onset versus offset responses. Methods: Cortical auditory evoked potentials (CAEPs) were recorded to the onset and offset of 3-second white noise stimuli in tinnitus and control groups matched in pairs by age, hearing, and sex (n = 26 total). Independent t-tests and 2-way mixed model ANOVA were used to evaluate onset-offset differences in amplitude, area, and latency of CAEP components by group. The predictive influence of tinnitus presence and associated participant characteristics on CAEP outcomes was assessed by multiple regression proportional reduction in error. Results: The tinnitus group had significantly larger onset minus offset P2 amplitudes (ΔP2 amplitudes) than control group participants. No other component variables differed significantly. ΔP2 amplitude was best predicted by tinnitus status and not significantly influenced by other variables such as hearing loss or age. Conclusions: Hypothesized reduced central inhibition and/or increased excitation in tinnitus participants was partially supported by a group difference in ΔP2 amplitude. Significance: This was the first study to evaluate CAEP onset minus offset differences to investigate changes in central excitation/inhibition in individuals with tinnitus versus controls in matched groups.

Original languageEnglish (US)
Pages (from-to)223-233
Number of pages11
JournalClinical Neurophysiology
Volume149
DOIs
StatePublished - May 2023

Keywords

  • CAEP
  • Excitation
  • Inhibition
  • Offset CAEP
  • P1-N1-P2
  • Tinnitus

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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