Norepinephrine depletion reduces the effects of social and olfactory experience

Catherine A. Cornwell-Jones, Michael W. Decker, Thomas Gianulli, Eileen L. Wright, James L. McGaugh

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Control juvenile rats adapted normally to a new home-cage bedding odor if they were caged with rats neonatally treated with 6-hydroxydopa, but not DSP-4. Neither social nor olfactory experience influenced preferences of NE-depleted rats. In some forebrain regions of controls caged with DSP-4 rats, monoamine concentrations were depressed and a metabolite elevated, suggesting the situation was stressful. DSP-4 treatment decreased the effect of footshock on hippocampal cholinergic activity, implying that NE depletion reduced sensitivity to stress. Thus, norepinephrine may modulate the biobehavioral effects of the postweaning olfactory and social environment.

Original languageEnglish (US)
Pages (from-to)643-649
Number of pages7
JournalBrain Research Bulletin
Volume25
Issue number5
DOIs
StatePublished - Nov 1990

Keywords

  • 6-Hydroxydopa
  • DSP-4
  • Frontal cortex
  • High affinity choline uptake
  • Hippocampus
  • Norepinephrine depletion
  • Odor preferences
  • Olfactory bulb
  • Olfactory cortex
  • Olfactory learning
  • Social experience

ASJC Scopus subject areas

  • Neuroscience(all)

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