Abstract
Control juvenile rats adapted normally to a new home-cage bedding odor if they were caged with rats neonatally treated with 6-hydroxydopa, but not DSP-4. Neither social nor olfactory experience influenced preferences of NE-depleted rats. In some forebrain regions of controls caged with DSP-4 rats, monoamine concentrations were depressed and a metabolite elevated, suggesting the situation was stressful. DSP-4 treatment decreased the effect of footshock on hippocampal cholinergic activity, implying that NE depletion reduced sensitivity to stress. Thus, norepinephrine may modulate the biobehavioral effects of the postweaning olfactory and social environment.
Original language | English (US) |
---|---|
Pages (from-to) | 643-649 |
Number of pages | 7 |
Journal | Brain Research Bulletin |
Volume | 25 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1990 |
Keywords
- 6-Hydroxydopa
- DSP-4
- Frontal cortex
- High affinity choline uptake
- Hippocampus
- Norepinephrine depletion
- Odor preferences
- Olfactory bulb
- Olfactory cortex
- Olfactory learning
- Social experience
ASJC Scopus subject areas
- General Neuroscience