Noradrenergic sympathetic blockade: Lack of effect on memory or retrograde amnesia

Debra B. Sternberg; Paul E. Gold; James L. McGaugh

doi:10.1016/0014-2999(82)90611-2

Noradrenergic sympathetic blockade: Lack of effect on memory or retrograde amnesia

Debra B. Sternberg, Paul E. Gold, James L. McGaugh

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Previous results indicate that pretraining peripheral injections of any of several adrenergic receptor antagonists can attenuate retrograde amnesia. The present experiment was an attempt to determine if the attenuation of amnesia was due to a blocking of peripheral sympathetic norepinephrine release. This experiment examined the effects on cortical stimulation-induced amnesia of pretreatment with bretylium, a drug which blocks release of norepinephrine from sympathetic nerve endings. The findings indicate that bretylium does not itself affect retention performance, nor does bretylium attenuate the production of retrograde amnesia.

Original language	English (US)
Pages (from-to)	133-136
Number of pages	4
Journal	European Journal of Pharmacology
Volume	81
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90611-2
State	Published - Jun 16 1982
Externally published	Yes

Keywords

Attenuation of retrograde amnesia
Bretylium Noradrenergic sympathetic blockade
Catecholamines and memory
Memory modulation

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(82)90611-2

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title = "Noradrenergic sympathetic blockade: Lack of effect on memory or retrograde amnesia",

abstract = "Previous results indicate that pretraining peripheral injections of any of several adrenergic receptor antagonists can attenuate retrograde amnesia. The present experiment was an attempt to determine if the attenuation of amnesia was due to a blocking of peripheral sympathetic norepinephrine release. This experiment examined the effects on cortical stimulation-induced amnesia of pretreatment with bretylium, a drug which blocks release of norepinephrine from sympathetic nerve endings. The findings indicate that bretylium does not itself affect retention performance, nor does bretylium attenuate the production of retrograde amnesia.",

keywords = "Attenuation of retrograde amnesia, Bretylium Noradrenergic sympathetic blockade, Catecholamines and memory, Memory modulation",

author = "Sternberg, {Debra B.} and Gold, {Paul E.} and McGaugh, {James L.}",

note = "Funding Information: The authors are grateful to Amar-Stone Laboratories, Inc. for the donation of Bretylol. This research was supported by",

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T1 - Noradrenergic sympathetic blockade

T2 - Lack of effect on memory or retrograde amnesia

AU - Sternberg, Debra B.

AU - Gold, Paul E.

AU - McGaugh, James L.

N1 - Funding Information: The authors are grateful to Amar-Stone Laboratories, Inc. for the donation of Bretylol. This research was supported by

PY - 1982/6/16

Y1 - 1982/6/16

N2 - Previous results indicate that pretraining peripheral injections of any of several adrenergic receptor antagonists can attenuate retrograde amnesia. The present experiment was an attempt to determine if the attenuation of amnesia was due to a blocking of peripheral sympathetic norepinephrine release. This experiment examined the effects on cortical stimulation-induced amnesia of pretreatment with bretylium, a drug which blocks release of norepinephrine from sympathetic nerve endings. The findings indicate that bretylium does not itself affect retention performance, nor does bretylium attenuate the production of retrograde amnesia.

AB - Previous results indicate that pretraining peripheral injections of any of several adrenergic receptor antagonists can attenuate retrograde amnesia. The present experiment was an attempt to determine if the attenuation of amnesia was due to a blocking of peripheral sympathetic norepinephrine release. This experiment examined the effects on cortical stimulation-induced amnesia of pretreatment with bretylium, a drug which blocks release of norepinephrine from sympathetic nerve endings. The findings indicate that bretylium does not itself affect retention performance, nor does bretylium attenuate the production of retrograde amnesia.

KW - Attenuation of retrograde amnesia

KW - Bretylium Noradrenergic sympathetic blockade

KW - Catecholamines and memory

KW - Memory modulation

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JO - European Journal of Pharmacology

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Noradrenergic sympathetic blockade: Lack of effect on memory or retrograde amnesia

Abstract

Keywords

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