Noradrenergic sympathetic blockade: Lack of effect on memory or retrograde amnesia

Debra B. Sternberg, Paul Ernest Gold, James L. McGaugh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Previous results indicate that pretraining peripheral injections of any of several adrenergic receptor antagonists can attenuate retrograde amnesia. The present experiment was an attempt to determine if the attenuation of amnesia was due to a blocking of peripheral sympathetic norepinephrine release. This experiment examined the effects on cortical stimulation-induced amnesia of pretreatment with bretylium, a drug which blocks release of norepinephrine from sympathetic nerve endings. The findings indicate that bretylium does not itself affect retention performance, nor does bretylium attenuate the production of retrograde amnesia.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalEuropean Journal of Pharmacology
Volume81
Issue number1
DOIs
StatePublished - Jun 16 1982
Externally publishedYes

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Keywords

  • Attenuation of retrograde amnesia
  • Bretylium Noradrenergic sympathetic blockade
  • Catecholamines and memory
  • Memory modulation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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