Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood: Microcirculation and viscosity effects

Joseph Chaiken, W. F. Finney, P. E. Knudson, K. P. Peterson, C. M. Peterson, X. Yang, R. S. Weinstock

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

We recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and then normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. A more careful comparison of tissue modulated spectra with static in vitro and invasive in vivo spectra suggests that there are small microcirculation differences between individuals resulting in some variability in their noninvasive quantitation. This variability is based on the mechanism for blood volume normalization and various means for obtaining necessary corrections are suggested. We present new clinical data from individuals and groups supporting this mechanism and suggesting how such measurements might also be used to quantify various microcirculation abnormalities.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT. Vo-Dinh, W.S. Grundfest, D.A. Benaron
Pages106-118
Number of pages13
Volume4254
DOIs
StatePublished - 2001
EventBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III - San Jose, CA, United States
Duration: Jan 21 2001Jan 22 2001

Other

OtherBiomedical Diagnostic, Guidance, and Surgical-Assist Systems III
CountryUnited States
CitySan Jose, CA
Period1/21/011/22/01

Fingerprint

Microcirculation
blood
Raman spectroscopy
Blood
Viscosity
Tissue
viscosity
blood volume
abnormalities
quantitative analysis
Raman scattering
Raman spectra
Chemical analysis

Keywords

  • Blood analysis
  • In-vivo Raman spectroscopy
  • Microcirculation
  • Noninvasive
  • Viscosity

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Chaiken, J., Finney, W. F., Knudson, P. E., Peterson, K. P., Peterson, C. M., Yang, X., & Weinstock, R. S. (2001). Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood: Microcirculation and viscosity effects. In T. Vo-Dinh, W. S. Grundfest, & D. A. Benaron (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4254, pp. 106-118) https://doi.org/10.1117/12.427952

Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood : Microcirculation and viscosity effects. / Chaiken, Joseph; Finney, W. F.; Knudson, P. E.; Peterson, K. P.; Peterson, C. M.; Yang, X.; Weinstock, R. S.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T. Vo-Dinh; W.S. Grundfest; D.A. Benaron. Vol. 4254 2001. p. 106-118.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chaiken, J, Finney, WF, Knudson, PE, Peterson, KP, Peterson, CM, Yang, X & Weinstock, RS 2001, Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood: Microcirculation and viscosity effects. in T Vo-Dinh, WS Grundfest & DA Benaron (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4254, pp. 106-118, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.427952
Chaiken J, Finney WF, Knudson PE, Peterson KP, Peterson CM, Yang X et al. Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood: Microcirculation and viscosity effects. In Vo-Dinh T, Grundfest WS, Benaron DA, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4254. 2001. p. 106-118 https://doi.org/10.1117/12.427952
Chaiken, Joseph ; Finney, W. F. ; Knudson, P. E. ; Peterson, K. P. ; Peterson, C. M. ; Yang, X. ; Weinstock, R. S. / Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood : Microcirculation and viscosity effects. Proceedings of SPIE - The International Society for Optical Engineering. editor / T. Vo-Dinh ; W.S. Grundfest ; D.A. Benaron. Vol. 4254 2001. pp. 106-118
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