Noninvasive, in-vivo, tissue modulated Raman spectroscopy of human blood: Microcirculation and viscosity effects

J. Chaiken, W. F. Finney, P. E. Knudson, K. P. Peterson, C. M. Peterson, X. Yang, R. S. Weinstock

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We recently presented the first Raman spectra of in vivo human blood. A brief review of how to obtain such spectra and then normalize them to the appropriate blood volume is given showing how to produce spectra that can be used for noninvasive quantitative analysis of blood in vivo. A more careful comparison of tissue modulated spectra with static in vitro and invasive in vivo spectra suggests that there are small microcirculation differences between individuals resulting in some variability in their noninvasive quantitation. This variability is based on the mechanism for blood volume normalization and various means for obtaining necessary corrections are suggested. We present new clinical data from individuals and groups supporting this mechanism and suggesting how such measurements might also be used to quantify various microcirculation abnormalities.

Original languageEnglish (US)
Pages (from-to)106-118
Number of pages13
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4254
DOIs
StatePublished - 2001

Keywords

  • Blood analysis
  • In-vivo Raman spectroscopy
  • Microcirculation
  • Noninvasive
  • Viscosity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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