Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: Blood chemistry

Joseph Chaiken, William F. Finney, Charles M. Peterson, Karen P. Peterson, Paul E. Knudson, Ruth S. Weinstock, Paul Lein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Citations (Scopus)

Abstract

We report the first noninvasive Raman spectra of in vivo human blood. `Tissue modulation' involves the use of thermal and/or mechanical stimulus to produce particular spatiotemporal distributions of mobile tissues, i.e. capillary blood, among nonmobile tissues, i.e. epidermis. Using this approach we have obtained three mutually independent lines of evidence, which unequivocally associate Raman spectra we have obtained with human blood. These spectra compare well with published spectra from other researchers of in vitro human blood. The results of a recent clinical study comparing our noninvasive in vivo spectroscopic measurements with simultaneous conventional in vitro measurements clearly demonstrate the efficacy of the tissue modulation approach. These results will be discussed in the context of noninvasive monitoring of a variety of analytes, i.e. glucose.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages135-143
Number of pages9
Volume3918
StatePublished - 2000
EventBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000

Other

OtherBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques
CitySan Jose, CA, USA
Period1/26/001/27/00

Fingerprint

blood
Blood
chemistry
Tissue
Infrared radiation
Raman scattering
Modulation
Raman spectra
modulation
epidermis
glucose
stimuli
Glucose
Monitoring

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Chaiken, J., Finney, W. F., Peterson, C. M., Peterson, K. P., Knudson, P. E., Weinstock, R. S., & Lein, P. (2000). Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: Blood chemistry. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3918, pp. 135-143). Society of Photo-Optical Instrumentation Engineers.

Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues : Blood chemistry. / Chaiken, Joseph; Finney, William F.; Peterson, Charles M.; Peterson, Karen P.; Knudson, Paul E.; Weinstock, Ruth S.; Lein, Paul.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918 Society of Photo-Optical Instrumentation Engineers, 2000. p. 135-143.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chaiken, J, Finney, WF, Peterson, CM, Peterson, KP, Knudson, PE, Weinstock, RS & Lein, P 2000, Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: Blood chemistry. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3918, Society of Photo-Optical Instrumentation Engineers, pp. 135-143, Biomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques, San Jose, CA, USA, 1/26/00.
Chaiken J, Finney WF, Peterson CM, Peterson KP, Knudson PE, Weinstock RS et al. Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: Blood chemistry. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918. Society of Photo-Optical Instrumentation Engineers. 2000. p. 135-143
Chaiken, Joseph ; Finney, William F. ; Peterson, Charles M. ; Peterson, Karen P. ; Knudson, Paul E. ; Weinstock, Ruth S. ; Lein, Paul. / Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues : Blood chemistry. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3918 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 135-143
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