Noninvasive, in vivo, tissue modulated near infrared vibrational spectroscopic study of mobile and static tissues: Blood chemistry

Joseph Chaiken, William F. Finney, Charles M. Peterson, Karen P. Peterson, Paul E. Knudson, Ruth S. Weinstock, Paul Lein

Research output: Contribution to journalConference article


We report the first noninvasive Raman spectra of in vivo human blood. `Tissue modulation' involves the use of thermal and/or mechanical stimulus to produce particular spatiotemporal distributions of mobile tissues, i.e. capillary blood, among nonmobile tissues, i.e. epidermis. Using this approach we have obtained three mutually independent lines of evidence, which unequivocally associate Raman spectra we have obtained with human blood. These spectra compare well with published spectra from other researchers of in vitro human blood. The results of a recent clinical study comparing our noninvasive in vivo spectroscopic measurements with simultaneous conventional in vitro measurements clearly demonstrate the efficacy of the tissue modulation approach. These results will be discussed in the context of noninvasive monitoring of a variety of analytes, i.e. glucose.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 2000
EventBiomedical Spectroscopy: Vibrational Spectroscopy and other Novel Techniques - San Jose, CA, USA
Duration: Jan 26 2000Jan 27 2000


ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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