Abstract
We have refined of our previously published tissue modulation technique for obtaining Raman spectra of blood in fingertip capillary beds. Results from the newest LighTouch device benefit from more consistent management of applied force and temperature and more consistent tissue placement. Comparing these more precisely obtained spectra with other spectra obtained from the same capillary beds using the natural heart driven pulse as modulation reveals essential aspects of microcirculation such as plasma skimming, the Faraeus effect and the Faraeus-Lindqvist effect. We discuss these results in the context of performing noninvasive quantitative analysis of blood and blood components in vivo. We show the first Raman spectra of human blood plasma noninvasive, in vivo.
| Original language | English (US) |
|---|---|
| Article number | 609305 |
| Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 6093 |
| DOIs | |
| State | Published - 2006 |
| Event | Biomedical Vibrational Spectroscopy III: Advances in Research and Industry - San Jose, CA, United States Duration: Jan 21 2006 → Jan 24 2006 |
Keywords
- Blood
- Faraeus effect
- Glucose
- In vivo
- Microcirculation
- Noninvasive
- Plasma
- Plasma skimming
- Raman
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging