Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma

J. Chaiken, Katie Ellis, Patrick Eslick, Lauren Piacente, Ethan Voss

Research output: Contribution to journalConference Articlepeer-review

6 Scopus citations


We have refined of our previously published tissue modulation technique for obtaining Raman spectra of blood in fingertip capillary beds. Results from the newest LighTouch device benefit from more consistent management of applied force and temperature and more consistent tissue placement. Comparing these more precisely obtained spectra with other spectra obtained from the same capillary beds using the natural heart driven pulse as modulation reveals essential aspects of microcirculation such as plasma skimming, the Faraeus effect and the Faraeus-Lindqvist effect. We discuss these results in the context of performing noninvasive quantitative analysis of blood and blood components in vivo. We show the first Raman spectra of human blood plasma noninvasive, in vivo.

Original languageEnglish (US)
Article number609305
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2006
EventBiomedical Vibrational Spectroscopy III: Advances in Research and Industry - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006


  • Blood
  • Faraeus effect
  • Glucose
  • In vivo
  • Microcirculation
  • Noninvasive
  • Plasma
  • Plasma skimming
  • Raman

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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