Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma

J. Chaiken, Katie Ellis, Patrick Eslick, Lauren Piacente, Ethan Voss

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We have refined of our previously published tissue modulation technique for obtaining Raman spectra of blood in fingertip capillary beds. Results from the newest LighTouch device benefit from more consistent management of applied force and temperature and more consistent tissue placement. Comparing these more precisely obtained spectra with other spectra obtained from the same capillary beds using the natural heart driven pulse as modulation reveals essential aspects of microcirculation such as plasma skimming, the Faraeus effect and the Faraeus-Lindqvist effect. We discuss these results in the context of performing noninvasive quantitative analysis of blood and blood components in vivo. We show the first Raman spectra of human blood plasma noninvasive, in vivo.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6093
DOIs
StatePublished - 2006
EventBiomedical Vibrational Spectroscopy III: Advances in Research and Industry - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Other

OtherBiomedical Vibrational Spectroscopy III: Advances in Research and Industry
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Fingerprint

Raman spectroscopy
Blood
Tissue
Plasmas
Raman scattering
Modulation
Microcirculation
Chemical analysis
Temperature

Keywords

  • Blood
  • Faraeus effect
  • Glucose
  • In vivo
  • Microcirculation
  • Noninvasive
  • Plasma
  • Plasma skimming
  • Raman

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Chaiken, J., Ellis, K., Eslick, P., Piacente, L., & Voss, E. (2006). Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6093). [609305] https://doi.org/10.1117/12.659219

Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma. / Chaiken, J.; Ellis, Katie; Eslick, Patrick; Piacente, Lauren; Voss, Ethan.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6093 2006. 609305.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chaiken, J, Ellis, K, Eslick, P, Piacente, L & Voss, E 2006, Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6093, 609305, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.659219
Chaiken J, Ellis K, Eslick P, Piacente L, Voss E. Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6093. 2006. 609305 https://doi.org/10.1117/12.659219
Chaiken, J. ; Ellis, Katie ; Eslick, Patrick ; Piacente, Lauren ; Voss, Ethan. / Noninvasive in vivo tissue and pulse modulated Raman spectroscopy of human capillary blood and plasma. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6093 2006.
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