Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues

Joseph Chaiken, William F. Finney, Karen Peterson, Charles Peterson, Paul E. Knudson, Ruth S. Weinstock, Paul Lein

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order-disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages89-97
Number of pages9
Volume3907
StatePublished - 2000
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X - San Jose, CA, USA
Duration: Jan 22 2000Jan 25 2000

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
CitySan Jose, CA, USA
Period1/22/001/25/00

Fingerprint

Lipids
lipids
Vibrational spectroscopy
Skin
Tissue
Infrared radiation
proteins
Infrared spectroscopy
fatty acids
spectroscopy
Proteins
Order disorder transitions
Cosmetics
Phospholipids
Chemical modification
disorders
Fatty acids
modulation
probes
Modulation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Chaiken, J., Finney, W. F., Peterson, K., Peterson, C., Knudson, P. E., Weinstock, R. S., & Lein, P. (2000). Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3907, pp. 89-97). Society of Photo-Optical Instrumentation Engineers.

Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. / Chaiken, Joseph; Finney, William F.; Peterson, Karen; Peterson, Charles; Knudson, Paul E.; Weinstock, Ruth S.; Lein, Paul.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907 Society of Photo-Optical Instrumentation Engineers, 2000. p. 89-97.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chaiken, J, Finney, WF, Peterson, K, Peterson, C, Knudson, PE, Weinstock, RS & Lein, P 2000, Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3907, Society of Photo-Optical Instrumentation Engineers, pp. 89-97, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, San Jose, CA, USA, 1/22/00.
Chaiken J, Finney WF, Peterson K, Peterson C, Knudson PE, Weinstock RS et al. Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907. Society of Photo-Optical Instrumentation Engineers. 2000. p. 89-97
Chaiken, Joseph ; Finney, William F. ; Peterson, Karen ; Peterson, Charles ; Knudson, Paul E. ; Weinstock, Ruth S. ; Lein, Paul. / Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 89-97
@inproceedings{db433c661f4f4f9c9ece5950f437720e,
title = "Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues",
abstract = "We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order-disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.",
author = "Joseph Chaiken and Finney, {William F.} and Karen Peterson and Charles Peterson and Knudson, {Paul E.} and Weinstock, {Ruth S.} and Paul Lein",
year = "2000",
language = "English (US)",
volume = "3907",
pages = "89--97",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Society of Photo-Optical Instrumentation Engineers",

}

TY - GEN

T1 - Noninvasive, in-vivo, near infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near surface tissues

AU - Chaiken, Joseph

AU - Finney, William F.

AU - Peterson, Karen

AU - Peterson, Charles

AU - Knudson, Paul E.

AU - Weinstock, Ruth S.

AU - Lein, Paul

PY - 2000

Y1 - 2000

N2 - We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order-disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.

AB - We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order-disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.

UR - http://www.scopus.com/inward/record.url?scp=0033691709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033691709&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033691709

VL - 3907

SP - 89

EP - 97

BT - Proceedings of SPIE - The International Society for Optical Engineering

PB - Society of Photo-Optical Instrumentation Engineers

ER -