Noninvasive blood analysis by tissue modulated NIR Raman spectroscopy

Joseph Chaiken; William F. Finney; Paul E. Knudson; Karen P. Peterson; Charles M. Peterson; Xiaoke Yang; Ruth S. Weinstock

doi:10.1117/12.438117

Noninvasive blood analysis by tissue modulated NIR Raman spectroscopy

Joseph Chaiken, William F. Finney, Paul E. Knudson, Karen P. Peterson, Charles M. Peterson, Xiaoke Yang, Ruth S. Weinstock

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We present tissue modulated Raman spectroscopy as a technique for noninvasively measuring the concentration of blood analytes in vivo. We present preliminary data used to determine the best methods for analyzing our data. These experiments provide additional proof that we are indeed able to obtain the spectra of human blood in vivo and noninvasively. We discuss differences between our spectra and spectra of bulk blood in vitro. We also discuss the variations between individuals and the impact of those variations on our noninvasive blood glucose measurements.

Original language	English (US)
Pages (from-to)	134-145
Number of pages	12
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4368
Issue number	1
DOIs	https://doi.org/10.1117/12.438117
State	Published - Aug 23 2001

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.438117

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abstract = "We present tissue modulated Raman spectroscopy as a technique for noninvasively measuring the concentration of blood analytes in vivo. We present preliminary data used to determine the best methods for analyzing our data. These experiments provide additional proof that we are indeed able to obtain the spectra of human blood in vivo and noninvasively. We discuss differences between our spectra and spectra of bulk blood in vitro. We also discuss the variations between individuals and the impact of those variations on our noninvasive blood glucose measurements.",

author = "Joseph Chaiken and Finney, {William F.} and Knudson, {Paul E.} and Peterson, {Karen P.} and Peterson, {Charles M.} and Xiaoke Yang and Weinstock, {Ruth S.}",

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AU - Chaiken, Joseph

AU - Finney, William F.

AU - Knudson, Paul E.

AU - Peterson, Karen P.

AU - Peterson, Charles M.

AU - Yang, Xiaoke

AU - Weinstock, Ruth S.

PY - 2001/8/23

Y1 - 2001/8/23

N2 - We present tissue modulated Raman spectroscopy as a technique for noninvasively measuring the concentration of blood analytes in vivo. We present preliminary data used to determine the best methods for analyzing our data. These experiments provide additional proof that we are indeed able to obtain the spectra of human blood in vivo and noninvasively. We discuss differences between our spectra and spectra of bulk blood in vitro. We also discuss the variations between individuals and the impact of those variations on our noninvasive blood glucose measurements.

AB - We present tissue modulated Raman spectroscopy as a technique for noninvasively measuring the concentration of blood analytes in vivo. We present preliminary data used to determine the best methods for analyzing our data. These experiments provide additional proof that we are indeed able to obtain the spectra of human blood in vivo and noninvasively. We discuss differences between our spectra and spectra of bulk blood in vitro. We also discuss the variations between individuals and the impact of those variations on our noninvasive blood glucose measurements.

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

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Noninvasive blood analysis by tissue modulated NIR Raman spectroscopy

Abstract

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