Non-equilibrium assembly of microtubules: From molecules to autonomous chemical robots

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Biological systems have evolved to harness non-equilibrium processes from the molecular to the macro scale. It is currently a grand challenge of chemistry, materials science, and engineering to understand and mimic biological systems that have the ability to autonomously sense stimuli, process these inputs, and respond by performing mechanical work. New chemical systems are responding to the challenge and form the basis for future responsive, adaptive, and active materials. In this article, we describe a particular biochemical-biomechanical network based on the microtubule cytoskeletal filament-itself a non-equilibrium chemical system. We trace the non-equilibrium aspects of the system from molecules to networks and describe how the cell uses this system to perform active work in essential processes. Finally, we discuss how microtubule-based engineered systems can serve as testbeds for autonomous chemical robots composed of biological and synthetic components.

Original languageEnglish (US)
Pages (from-to)5570-5587
Number of pages18
JournalChemical Society Reviews
Volume46
Issue number18
DOIs
StatePublished - Sep 21 2017
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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