Non-canonical lipoproteins with programmable assembly and architecture

Md Shahadat Hossain; Corina Maller; Yinghui Dai; Shikha Nangia; Davoud Mozhdehi

doi:10.1039/d0cc03271a

Non-canonical lipoproteins with programmable assembly and architecture

Md Shahadat Hossain, Corina Maller, Yinghui Dai, Shikha Nangia, Davoud Mozhdehi

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The substrate promiscuity of an acyltransferase is leveraged to synthesize artificial lipoproteins bearing a non-canonical PTM (ncPTM). The non-canonical functionality of these lipoproteins results in a distinctive hysteretic assembly—absent from the canonical lipoproteins—and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity. This study demonstrates the promise of expanding the repertoire of PTMs for the development of nanomaterials with a unique assembly and function.

Original language	English (US)
Pages (from-to)	10281-10284
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	71
DOIs	https://doi.org/10.1039/d0cc03271a
State	Published - Sep 14 2020

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/d0cc03271a

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AU - Hossain, Md Shahadat

AU - Maller, Corina

AU - Dai, Yinghui

AU - Nangia, Shikha

AU - Mozhdehi, Davoud

N1 - Publisher Copyright: © The Royal Society of Chemistry 2020.

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AB - The substrate promiscuity of an acyltransferase is leveraged to synthesize artificial lipoproteins bearing a non-canonical PTM (ncPTM). The non-canonical functionality of these lipoproteins results in a distinctive hysteretic assembly—absent from the canonical lipoproteins—and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity. This study demonstrates the promise of expanding the repertoire of PTMs for the development of nanomaterials with a unique assembly and function.

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Non-canonical lipoproteins with programmable assembly and architecture

Abstract

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