New frontiers: Discovering cilia-independent functions of cilia proteins

Anastassiia Vertii, Alison Bright, Benedicte Delaval, Heidi Hehnly, Stephen Doxsey

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

In most vertebrates, mitotic spindles and primary cilia arise from a common origin, the centrosome. In non-cycling cells, the centrosome is the template for primary cilia assembly and, thus, is crucial for their associated sensory and signaling functions. During mitosis, the duplicated centrosomes mature into spindle poles, which orchestrate mitotic spindle assembly, chromosome segregation, and orientation of the cell division axis. Intriguingly, both cilia and spindle poles are centrosome-based, functionally distinct structures that require the action of microtubule-mediated, motor-driven transport for their assembly. Cilia proteins have been found at non-cilia sites, where they have distinct functions, illustrating a diverse and growing list of cellular processes and structures that utilize cilia proteins for crucial functions. In this review, we discuss cilia-independent functions of cilia proteins and re-evaluate their potential contributions to "cilia" disorders.

Original languageEnglish (US)
Pages (from-to)1275-1287
Number of pages13
JournalEMBO Reports
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • Centrosome
  • Cilia
  • Ciliopathies
  • IFT
  • MTOC

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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