New dimensions of asymmetric division in vertebrates

Anastassiia Vertii, Paul D. Kaufman, Heidi Hehnly, Stephen Doxsey

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Traditionally, we imagine that cell division gives rise to two identical daughter cells. Nevertheless, all cell divisions, to some degree, display asymmetry. Asymmetric cell division is defined as the generation of two daughter cells with different physical content and/or developmental potential. Several organelles and cellular components including the centrosome, non-coding RNA, chromatin, and recycling endosomes are involved in the process of asymmetric cell division. Disruption of this important process is known to induce profound defects in development, the immune response, regeneration of tissues, aging, and cancer. Here, we discuss recent advances that expand our understanding of the mechanisms and consequences of asymmetric cell division in vertebrate organisms.

Original languageEnglish (US)
Pages (from-to)87-102
Number of pages16
JournalCytoskeleton
Volume75
Issue number3
DOIs
StatePublished - Mar 1 2018
Externally publishedYes

Fingerprint

Asymmetric Cell Division
Vertebrates
Cell Division
Centrosome
Untranslated RNA
Endosomes
Organelles
Chromatin
Regeneration
Neoplasms

Keywords

  • aging
  • asymmetric division
  • cancer
  • cell division
  • mitosis
  • non-coding RNA
  • regeneration
  • stem cell
  • T cells

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

Cite this

New dimensions of asymmetric division in vertebrates. / Vertii, Anastassiia; Kaufman, Paul D.; Hehnly, Heidi; Doxsey, Stephen.

In: Cytoskeleton, Vol. 75, No. 3, 01.03.2018, p. 87-102.

Research output: Contribution to journalReview article

Vertii, A, Kaufman, PD, Hehnly, H & Doxsey, S 2018, 'New dimensions of asymmetric division in vertebrates', Cytoskeleton, vol. 75, no. 3, pp. 87-102. https://doi.org/10.1002/cm.21434
Vertii, Anastassiia ; Kaufman, Paul D. ; Hehnly, Heidi ; Doxsey, Stephen. / New dimensions of asymmetric division in vertebrates. In: Cytoskeleton. 2018 ; Vol. 75, No. 3. pp. 87-102.
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