TY - JOUR
T1 - Neuroendocrine effects on memory in aged rodents and humans
AU - Gold, P. E.
AU - Stone, W. S.
N1 - Funding Information:
Supported by research grants from the National Institute of Mental Health (MH 31141), the Office of Naval Research (N00014-85-K0472), and the American Diabetes Association. W.S.S. is the recipient of an NIA postdoctoral fellowship (AG 05408).
PY - 1988
Y1 - 1988
N2 - Considerable evidence indicates that epinephrine regulates memory storage processing in young animals. Recent findings suggest that hyperglycemia subsequent to epinephrine release or injection may mediate the hormone's effects on memory. This paper reviews findings demonstrating that epinephrine and glucose treatments attenuate age-related memory impairments in rodents and humans. Additional results suggest that, in aged human and animal subjects, poor glucose regulation predicts memory performance of individual subjects.
AB - Considerable evidence indicates that epinephrine regulates memory storage processing in young animals. Recent findings suggest that hyperglycemia subsequent to epinephrine release or injection may mediate the hormone's effects on memory. This paper reviews findings demonstrating that epinephrine and glucose treatments attenuate age-related memory impairments in rodents and humans. Additional results suggest that, in aged human and animal subjects, poor glucose regulation predicts memory performance of individual subjects.
KW - Aging, memory dysfunction
KW - Epinephrine, effects on memory
KW - Glucose regulation and memory
KW - Glucose, effects on memory
KW - Memory, neuroendocrine regulation
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U2 - 10.1016/S0197-4580(88)80136-2
DO - 10.1016/S0197-4580(88)80136-2
M3 - Review article
C2 - 3062477
AN - SCOPUS:0024160444
VL - 9
SP - 709
EP - 717
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - C
ER -