Neuroendocrine effects on memory in aged rodents and humans

P. E. Gold, W. S. Stone

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Considerable evidence indicates that epinephrine regulates memory storage processing in young animals. Recent findings suggest that hyperglycemia subsequent to epinephrine release or injection may mediate the hormone's effects on memory. This paper reviews findings demonstrating that epinephrine and glucose treatments attenuate age-related memory impairments in rodents and humans. Additional results suggest that, in aged human and animal subjects, poor glucose regulation predicts memory performance of individual subjects.

Original languageEnglish (US)
Pages (from-to)709-717
Number of pages9
JournalNeurobiology of Aging
Issue numberC
StatePublished - 1988
Externally publishedYes


  • Aging, memory dysfunction
  • Epinephrine, effects on memory
  • Glucose regulation and memory
  • Glucose, effects on memory
  • Memory, neuroendocrine regulation

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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