Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury

Dennis J. Stelzner (Inventor), Donna J. Osterhout (Inventor), Julie M. Hasenwinkel (Inventor)

Research output: Patent

Abstract

A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided.
Original languageEnglish (US)
Patent number8,765,122
StatePublished - Sep 1 2011

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  • Cite this

    Stelzner, D. J., Osterhout, D. J., & Hasenwinkel, J. M. (2011). Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury. (Patent No. 8,765,122).