Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials

Mary Monroe, Alexandra D. Easley, Katie Grant, Grace K. Fletcher, Calla Boyer, Duncan J. Maitland

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Despite a number of clinically available hemostats, uncontrolled bleeding is the primary cause of trauma-related death. Shape-memory polymer (SMP) foams have a number of desirable properties for use as hemostats, including shape recovery to enable delivery into bleed sites, biocompatibility, and rapid blood clotting. To expand upon this material system, the current work aims to incorporate phenolic acids, which are honey-based antimicrobial agents, into SMP foams. We showed that cinnamic acid (CA) can be utilized as a monomer in SMP synthesis to provide foams with comparable pore structure and retained cytocompatibility. The addition of CA enabled tuning of thermal and shape-memory properties within clinically relevant ranges. Furthermore, the modified foams demonstrated initial and sustained antimicrobial effects against gram-positive and gram-negative bacteria. These multifunctional scaffolds demonstrate potential for use as hemostats to improve upon current hemorrhage treatments and provide a new tool in tuning the biological and material properties of SMP foams.

Original languageEnglish (US)
Pages (from-to)1999-2008
Number of pages10
JournalChemPhysChem
Volume19
Issue number16
DOIs
StatePublished - Aug 17 2018
Externally publishedYes

Keywords

  • antibiotics
  • phenolic acid
  • polymers
  • shape memory
  • synthesis design

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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    Monroe, M., Easley, A. D., Grant, K., Fletcher, G. K., Boyer, C., & Maitland, D. J. (2018). Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials. ChemPhysChem, 19(16), 1999-2008. https://doi.org/10.1002/cphc.201701015