Motor-driven dynamics of cytoskeletal filaments in motility assays

Shiladitya Banerjee, M. Cristina Marchetti, Kristian Müller-Nedebock

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We model analytically the dynamics of a cytoskeletal filament in a motility assay. The filament is described as rigid rod free to slide in two dimensions. The motor proteins consist of polymeric tails tethered to the plane and modeled as linear springs and motor heads that bind to the filament. As in related models of rigid and soft two-state motors, the binding and unbinding dynamics of the motor heads and the dependence of the transition rates on the load exerted by the motor tails play a crucial role in controlling the filament's dynamics. Our work shows that the filament effectively behaves as a self-propelled rod at long times, but with non-Markovian noise sources arising from the coupling to the motor binding and unbinding dynamics. The effective propulsion force of the filament and the active renormalization of the various friction and diffusion constants are calculated in terms of microscopic motor and filament parameters. These quantities could be probed by optical force microscopy.

Original languageEnglish (US)
Article number011914
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume84
Issue number1
DOIs
StatePublished - Jul 18 2011

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Motor-driven dynamics of cytoskeletal filaments in motility assays'. Together they form a unique fingerprint.

Cite this