Monomeric Pyrophosphate complexes and Methods of Treatment Using the Complexes

Robert Doyle (Inventor)

Research output: Patent

Abstract

The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.
Original languageEnglish (US)
StatePublished - Apr 21 2011

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Coordination Complexes
Cells
Phenanthrolines
Patents and inventions
diphosphoric acid

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title = "Monomeric Pyrophosphate complexes and Methods of Treatment Using the Complexes",
abstract = "The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.",
author = "Robert Doyle",
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type = "Patent",

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AU - Doyle, Robert

PY - 2011/4/21

Y1 - 2011/4/21

N2 - The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.

AB - The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.

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