TY - PAT
T1 - Monomeric Pyrophosphate complexes and Methods of Treatment Using the Complexes
AU - Doyle, Robert
PY - 2011/4/21
Y1 - 2011/4/21
N2 - The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.
AB - The present invention involves pyrophosphate bridged coordination complexes and the treatment of medical conditions, such as cancer, using the pyrophosphate bridged coordination complexes. The pyrophosphate bridged coordination complexes include four new compounds, [Co(phen)2(H2P2O7)].4H2O (1.4H2O), [Ni(phen)2(H2P2O7)].8H2O (2.8H2O), [Cu(phen)(H2O)(H2P2O7)], and {[Cn(phen)(H2O)(P2O7)] [Na2(H2O)8]}.6H2O(4.14H2O) found effective for treating cancer cells. The pyrophosphate bridged coordination complexes also include three previously reported compounds, {[Ni(phen)2]2(μ-P2O7)}.27H2O (compound 11), {[Cu(phen)(H2O)]2(μ-P2O7)}.8H2O (compound 12), and {[Co(phen)2]2(μ-25 P2O7)}.6MeOH (compound 13), (where phen is 1,1 0′-phenanthroline), whose effectiveness in treating cancer cells was previously unknown.
M3 - Patent
ER -