Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

Paul E. Gold; Richard L. Delanoy; James Merrin

doi:10.1016/0006-8993(84)91124-7

Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

Paul E. Gold, Richard L. Delanoy, James Merrin

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development of LTP in a dose-related manner comparable to that seen previously in behavioral studies. Such results suggest that the development of this long-lasting electrophysiological change can be regulated by peripheral catecholamine levels in a manner analogous to that seen in behavioral studies of memory.

Original language	English (US)
Pages (from-to)	103-107
Number of pages	5
Journal	Brain Research
Volume	305
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91124-7
State	Published - Jul 2 1984
Externally published	Yes

Keywords

amphetamine
dentate gyrus
epinephrine
long-term potentiation
memory modulation

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)91124-7

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AB - Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development of LTP in a dose-related manner comparable to that seen previously in behavioral studies. Such results suggest that the development of this long-lasting electrophysiological change can be regulated by peripheral catecholamine levels in a manner analogous to that seen in behavioral studies of memory.

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KW - memory modulation

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Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

Abstract

Keywords

ASJC Scopus subject areas

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