Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins

Najat Haj-Yahya; Mahmood Haj-Yahya; Carlos A. Castañeda; Liat Spasser; Hosahalli P. Hemantha; Muhammad Jbara; Marlin Penner; Aaron Ciechanover; David Fushman; Ashraf Brik

doi:10.1002/anie.201306118

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins

Najat Haj-Yahya, Mahmood Haj-Yahya, Carlos A. Castañeda, Liat Spasser, Hosahalli P. Hemantha, Muhammad Jbara, Marlin Penner, Aaron Ciechanover, David Fushman, Ashraf Brik

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

In every direction: Chemical protein synthesis allows the construction of 14 di-ubiquitin analogues modified in the vicinity of the isopeptide bond to examine their behavior with deubiquitinases and ubiquitin binding domains. The results set the ground for the generation of unique probes for studying the interactions of these chains with various ubiquitin-interacting proteins.

Original language	English (US)
Pages (from-to)	11149-11153
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	42
DOIs	https://doi.org/10.1002/anie.201306118
State	Published - Oct 11 2013
Externally published	Yes

Keywords

deubiquitinases
peptide ligation
protein synthesis
ubiquitin chains
ubiquitination

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201306118

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Haj-Yahya, N., Haj-Yahya, M., Castañeda, C. A., Spasser, L., Hemantha, H. P., Jbara, M., Penner, M., Ciechanover, A., Fushman, D., & Brik, A. (2013). Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins. Angewandte Chemie - International Edition, 52(42), 11149-11153. https://doi.org/10.1002/anie.201306118

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins. / Haj-Yahya, Najat; Haj-Yahya, Mahmood; Castañeda, Carlos A. et al.
In: Angewandte Chemie - International Edition, Vol. 52, No. 42, 11.10.2013, p. 11149-11153.

Research output: Contribution to journal › Article › peer-review

Haj-Yahya, N, Haj-Yahya, M, Castañeda, CA, Spasser, L, Hemantha, HP, Jbara, M, Penner, M, Ciechanover, A, Fushman, D & Brik, A 2013, 'Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins', Angewandte Chemie - International Edition, vol. 52, no. 42, pp. 11149-11153. https://doi.org/10.1002/anie.201306118

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Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: Organic chemistry applied to synthetic proteins

Abstract

Keywords

ASJC Scopus subject areas

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